Genetically Engineered Psoriasis Model Development Services

Genetically engineered psoriasis models are developed through targeted modifications of genes involved in immune regulation, keratinocyte proliferation, or signaling pathways in psoriasis. Unlike induced models, which rely on chemical induction or immune activation, genetically engineered models provide researchers with highly specific and reproducible systems to investigate the molecular mechanisms driving psoriasis.

Fig. 1 Some of the biochemical pathways manipulated in transgenic mouse models of psoriasis: STAT3, AP-1, and the NF-κB pathways. (Gudjonsson JE, et al, 2007)

Ace Therapeutics offers specialized genetically engineered psoriasis model development services, enabling researchers and pharmaceutical companies to analyze mechanisms of psoriasis and accelerate the development of anti-psoriatic drugs. Our services include animal model design, genetic engineering, breeding, validation, and phenotypic characterization.

Types of Genetically Engineered Psoriasis Models We Can Develop

Psoriasis Mouse Models With Targeted Manipulation of the STAT3 Pathway

At Ace Therapeutics, we develop psoriasis mouse models with targeted manipulation of the signal transducer and activator of transcription 3 (STAT3) pathway, a critical regulator of keratinocyte proliferation and immune activation. For example, we provide K5.Stat3C transgenic mice, which serve as valuable models for investigating the IL-23/IL-17 signaling axis and the complex interactions between keratinocytes and immune cells in psoriasis. Our company provides a complete range of services, including model development and phenotype characterization, enabling clients to evaluate the efficacy of novel anti-psoriatic drugs targeting STAT3 signaling.

Psoriasis Mouse Models With Targeted Manipulation of the AP-1 Transcription Factor Family

Alterations in the activator protein-1 (AP-1) transcription factor family disrupt epidermal homeostasis and contribute to the development of psoriatic lesions characterized by hyperkeratosis and immune infiltration. Our company offers psoriasis models with targeted manipulation of the AP-1 transcription factor family, including JunB and c-Jun. Our models support in-depth investigation of keratinocyte-mediated inflammatory pathways and the evaluation of therapeutic candidates targeting psoriasis.

Psoriasis Mouse Models With Targeted Manipulation of the NF-κB Pathway

NF-κB activation in keratinocytes or immune cells drives cytokine production, leading to psoriasis-like skin lesions. We provide psoriasis mouse models with targeted manipulation of the NF-κB pathway, such as keratin 14 Cre transgenic mice and K5-IKKa transgenic mice.

Psoriasis Mouse Models With Targeted Manipulation of the TGF-β Pathway

Altered transforming growth factor (TGF)-β activity contributes to loss of barrier integrity, immune imbalance, and chronic skin inflammation. We provide psoriasis mouse models with targeted modifications of the TGF-β pathway, in which excessive TGF-β activity induces psoriasis-like skin inflammation, serving as a model for investigating mechanisms of psoriasis and assessing potential therapeutic interventions.

Psoriasis Mouse Models Based on Targeted Cytokine Expression

Our company also supports the development and characterization of psoriasis mouse models based on the targeted overexpression of cytokines, including TNF-α, IFN-γ, and IL-17A. Additionally, we help clients evaluate the efficacy of anti-psoriatic drugs targeting these cytokines.

At Ace Therapeutics, we combine deep expertise in dermatology research with advanced genetic engineering technologies to provide customized genetically engineered psoriasis model development services. For more information on genetically engineered psoriasis model development services or to discuss how we can support your research, please do not hesitate to contact us.