Spontaneous Models of Psoriasis Development Services

Spontaneous models of psoriasis represent a unique category of preclinical tools in which psoriasis phenotypes arise naturally due to genetic mutations rather than requiring external triggers. These models are particularly valuable because they often exhibit chronic skin inflammation that reflects critical aspects of human psoriasis, including epidermal hyperplasia, scaling, erythema, and immune cell infiltration.

Fig. 1 A simplified diagram illustrating the structural alterations in human skin affected by psoriasis. (Lin ZC, et al., 2024)

Ace Therapeutics specializes in the development and characterization of spontaneous models of psoriasis, offering robust and reproducible experimental models for preclinical efficacy evaluation and drug development.

Types of Spontaneous Models of Psoriasis We Can Develop

Homozygous Asebia (Scd1^ab/Scd1^ab) Mice

At Ace Therapeutics, we provide homozygous asebia (Scd1^ab/Scd1^ab) mouse models carrying mutations in the stearoyl-CoA desaturase 1 (Scd1) gene. These mice lack functional sebaceous glands, which leads to epidermal hyperplasia, scaling, and skin inflammation that resemble psoriasis-like lesions. Our company offers comprehensive services for colony establishment and phenotype characterization to support preclinical drug efficacy evaluation.

Flaky Skin (Ttc7^fsn/Ttc7^fsn) Mice

Our company offers flaky skin (Ttc7^fsn/Ttc7^fsn) mouse models with mutations in the tetratricopeptide repeat domain 7A (Ttc7a) gene, characterized by severe skin inflammation, epidermal hyperkeratosis, and immune cell infiltration. We provide comprehensive services based on these models, including drug efficacy assessment, dose-response analysis, and histopathological evaluation.

Chronic Proliferative Dermatitis (Sharpin^cpdm/Sharpin^cpdm) Mice

We also provide Sharpin^cpdm/Sharpin^cpdm mouse models, which have mutations in the SHANK-associated RH domain interacting protein (Sharpin) gene. This defect disrupts NF-κB signaling and drives severe, chronic dermatitis characterized by hallmark features, including epidermal thickening, scaling, and lymphocyte infiltration. Our company provides end-to-end services from breeding to phenotypic characterization, assisting researchers in exploring immune-mediated pathways and evaluating novel anti-psoriatic therapeutics.

How Do We Characterize Spontaneous Models of Psoriasis?

By combining histological, molecular, and functional analysis services, we support clients in characterizing spontaneous models of psoriasis for preclinical research.

Histopathology Services

We offer detailed histopathological examinations of psoriasis lesions, assessing epidermal hyperplasia, parakeratosis, and immune cell infiltration in spontaneous models of psoriasis.

Barrier Function Assessment Services

We help clients assess transepidermal water loss, lipid abnormalities, and barrier defects in spontaneous models of psoriasis, which are critical hallmarks of psoriasis pathophysiology.

Molecular Profiling Services

Our experts help clients characterize molecular signatures associated with psoriasis by analyzing the expression of IL-17, IL-23, TNF-α, keratins, and other biomarkers, enabling analysis of inflammatory pathways in spontaneous models of psoriasis.

Immunophenotyping Services

We use advanced flow cytometry and immunohistochemistry to identify immune cell populations, including pathogenic T cells, dendritic cells, and macrophages, which drive psoriasis-like inflammation in spontaneous models of psoriasis.

Ace Therapeutics develops and characterizes spontaneous models of psoriasis to support clients in preclinical drug discovery and efficacy evaluation. For more information on spontaneous models of psoriasis or to discuss how we can support your research, please do not hesitate to contact us .