Oral Antipsoriatic Drug Development Services

Psoriasis is a chronic, immune-mediated disease that affects millions worldwide, characterized by hyperproliferation of keratinocytes, immune cell infiltration, and systemic comorbidities. Oral antipsoriatic drugs remain an indispensable treatment modality due to their convenience, systemic activity, and suitability for long-term management. Unlike topical therapies, oral formulations can address both cutaneous lesions and systemic inflammation, improving patient compliance and quality of life.

Leveraging psoriasis models and comprehensive preclinical services, Ace Therapeutics provides end-to-end solutions to accelerate the discovery and development of oral antipsoriatic drugs. Our services are designed to meet the needs of pharmaceutical companies, biotechnology enterprises, and academic institutions seeking reliable partners in therapeutic innovation.

Types of Oral Antipsoriatic Drugs We Can Develop

Oral Systemic Therapies

Our company provides services to help clients optimize oral systemic therapies such as methotrexate, cyclosporine, and acitretin, with a focus on improved formulations and reduced toxicity. Our services also include analog design, preclinical efficacy evaluation, and comprehensive safety assessment to support the development of oral antipsoriatic drugs that achieve an optimal balance between efficacy and safety.

Targeted Oral Small Molecule Inhibitors

We specialize in the discovery and development of oral small molecules for psoriasis, targeting key pathogenic pathways such as JAK/STAT, PDE4, TYK2, and RORγt. Our scientific team provides drug screening, lead optimization, and comprehensive pharmacokinetic profiling services to support clients in optimal bioavailability and therapeutic efficacy.

Oral Immunomodulators

We help clients identify, validate, and develop oral immunomodulators that regulate T-cell activity, cytokine release, and innate immune responses. Our services enable clients to conduct in-depth functional screening, mechanism-of-action studies, efficacy assessments, and safety evaluations, thereby accelerating the development of oral immunomodulators for psoriasis.

Comprehensive Oral Antipsoriatic Drug Development Services

Target Validation and Drug Discovery

Our company offers transcriptomics, proteomics, and multi-omics services to identify psoriasis-associated pathways and therapeutic targets. We apply a range of molecular and cellular approaches to validate therapeutic targets in psoriasis models. We also provide high-throughput compound screening to accelerate the identification of promising oral antipsoriatic drug candidates.

Preclinical Efficacy Testing

We offer preclinical efficacy testing using a wide range of validated psoriasis models. Our company provides imiquimod-induced psoriasis models, xenotransplantation models of psoriasis, and genetically engineered models to evaluate drug efficacy. We help clients analyze whether anti-psoriatic drug candidates exhibit therapeutic effects, including keratinocyte hyperproliferation reduction, cytokine modulation, and immune infiltration suppression.

Pharmacokinetic (PK) Studies

Our company offers in vitro ADME assays, bioavailability testing, and in vivo PK studies in different species to analyze absorption, distribution, metabolism, and excretion properties. We assess oral drug stability, solubility, and permeability to guide formulation optimization and dosing strategies.

Toxicology Studies

We provide comprehensive toxicology studies for the safety evaluation of oral antipsoriatic drug candidates. Our company offers acute, subchronic, and chronic toxicity studies according to client requirements. We also assess organ-specific toxicity, immunotoxicity, genotoxicity, and off-target effects through both in vitro and in vivo testing platforms.

By combining innovative scientific approaches and rigorous preclinical testing, Ace Therapeutics provides our clients with comprehensive, customized solutions that accelerate the development of oral anti-psoriatic drugs. Contact us today to learn more about how we can support your drug development journey and help you achieve success in the competitive field of psoriasis therapeutics.