Pig Models of Psoriasis Development Services

Pig skin closely resembles human skin in thickness, epidermal stratification, dermal structure, vascularization, and immune cell composition. These features make pig models particularly valuable for psoriasis research, as they more accurately recapitulate the pathological manifestations of psoriasis compared with rodent models. By leveraging genetic engineering and cytokine-induction strategies, pig models of psoriasis mimic human psoriatic pathology, including keratinocyte hyperproliferation, parakeratosis, and inflammatory infiltration.

Ace Therapeutics specializes in the development, characterization, and application of pig models of psoriasis to support the discovery and development of innovative anti-psoriatic drugs.

Types of Pig Models of Psoriasis We Can Develop

Transgenic Pig Models of Psoriasis

At Ace Therapeutics, we develop transgenic pig models of psoriasis using genetic engineering strategies to introduce human genes into porcine skin. For example, we can develop transgenic pigs co-expressing human integrins such as α2 and β1 in suprabasal epidermal layers, leading to psoriasiform skin lesions.

Our services span from psoriasis model development to detailed histopathological characterization of psoriatic hallmarks, such as hypogranulosis, epidermal hyperplasia, and parakeratosis. In addition, we offer comprehensive immunological profiling services, with a focus on T-lymphocyte infiltration and cytokine expression patterns associated with psoriasis pathology.

IL-23-Induced Miniature Swine Models of Psoriasis

Our team also develops the IL-23-induced miniature swine models, in which localized intradermal delivery of IL-23 triggers robust psoriasis phenotypes. These include erythema, scaling, thickened epidermis, and infiltration of immune cell subsets associated with human psoriasis.

To support preclinical development, we provide drug efficacy testing services, including evaluation of biologics and small molecules, to assess their ability to suppress IL-23-driven responses, normalize epidermal structure, and reduce immune activation. Monitoring of psoriatic lesion regression, evaluation of body weight, and quantification of key histological and immunological changes are also available as part of our comprehensive services.

Psoriasis Research and Drug Evaluation Services Using Pig Models

Ace Therapeutics uses pig models of psoriasis to offer a broad range of research and preclinical evaluation services, supporting mechanism studies and the development of anti-psoriatic drugs.

• Mechanism of action studies. We use pig models to support clients in analyzing the molecular and cellular mechanisms underlying psoriasis, with a focus on cytokine pathways, keratinocyte dynamics, and immune cell infiltration that drive disease progression.
• Preclinical drug evaluation. We assist clients in evaluating the efficacy of anti-psoriatic drugs in pig models of psoriasis. Our experts quantify lesion improvement through clinical scoring, imaging-based measurements, and histopathology, supported by molecular readouts such as cytokine expression and immune cell profiling.
• Safety and toxicity assessment. Leveraging the anatomical and physiological similarities between pig skin and human skin, we offer dermal and systemic safety evaluations to enhance the predictive value of toxicity studies.

With strong anatomical and immunological parallels to humans, pig models of psoriasis offer unparalleled advantages for advancing psoriasis research and therapeutic evaluation. At Ace Therapeutics, we provide custom transgenic pig and IL-23-induced miniature swine models, along with comprehensive therapeutic evaluation services, to help our clients accelerate the development of novel anti-psoriatic drugs. For more information on pig models of psoriasis or to discuss how we can support your research, please do not hesitate to contact us .