Xenotransplantation Models of Psoriasis Development Services

Xenotransplantation models of psoriasis are developed by grafting human psoriatic skin or healthy human skin onto immunodeficient mice, followed by the induction of immune responses. These models replicate the histological, molecular, and immunological hallmarks of human psoriasis, including epidermal hyperplasia, keratinocyte hyperproliferation, immune cell infiltration, and cytokine dysregulation.

Fig. 1 Histological comparison of normal human (a, d), mouse skin (b, e), and human-mouse xenograft (c, f). (Gudjonsson JE, et al, 2007)

Ace Therapeutics provides services to develop xenotransplantation models of psoriasis to support the evaluation of therapeutic candidates targeting psoriasis. These models are invaluable for evaluating the efficacy of anti-psoriatic drugs and studying immune responses.

Types of Xenotransplantation Models of Psoriasis We Can Develop

The Psoriasis SCID Mouse Model:

Severe combined immunodeficiency (SCID) mice are widely used as models in psoriasis research. By transplanting human psoriatic skin onto SCID mice, we develop reliable xenotransplantation models of psoriasis that enable the investigation of epidermal proliferation and keratinocyte-driven inflammation in the absence of host immune rejection. These models are particularly valuable for evaluating topical and systemic therapeutic candidates.

Psoriatic Skin Grafted onto AGR129 Mice

We develop psoriasis xenotransplantation models based on AGR129 mice, which are immunodeficient and lack type I and type III interferon receptors as well as recombinase-activating gene 2. The genetic background of the AGR129 mice supports human T-cell engraftment, which is particularly valuable for studying T-cell-mediated pathogenesis of psoriasis. Our scientists assist clients in studying the effects of various targeted therapeutics using these models.

How Do We Develop Xenotransplantation Models of Psoriasis?

At Ace Therapeutics, we follow a rigorous and standardized process to develop xenotransplantation models of psoriasis.

Human Tissue Acquisition and Preparation

We begin psoriasis model development services with the acquisition of human skin samples. Preconditioning of the skin may involve exposure to specific cytokines or growth factors to mimic the psoriasis environment.

Xenotransplantation onto Immunodeficient Mouse Models

Our experts implant human skin samples onto the dorsal region of immunodeficient mice, such as scid/scid and AGR129 strains. The surgical procedure is performed under sterile conditions to minimize the risk of infection.

Characterization of Xenotransplantation Models of Psoriasis

We provide a range of techniques to monitor the development of psoriasis-like features. Our experts use histological analyses, immunohistochemistry, and molecular assays to help clients analyze keratinocyte proliferation, inflammatory cell infiltration, and the expression of biomarkers in psoriasis.

Preclinical Evaluation of Anti-Psoriatic Efficacy

We use xenotransplantation models of psoriasis to assist clients in preclinical evaluation of the efficacy of anti-psoriatic drugs. We offer services to evaluate the anti-psoriatic efficacy of topical formulations, systemic biologics, and novel small molecules. Readouts include clinical scoring of lesion severity, histopathological improvement, and cytokine modulation.

At Ace Therapeutics, we offer comprehensive xenotransplantation models of psoriasis, combining human tissue preparation, surgical implantation onto immunodeficient mice, and in-depth model characterization. For more information on xenotransplantation models of psoriasis or to discuss how we can support your research, please do not hesitate to contact us .