Imiquimod-Induced NHP Psoriasis Models
The imiquimod (IMQ)-induced non-human primate (NHP) psoriasis model provides a highly translational system for investigating the pathogenesis of psoriasis and evaluating novel therapeutics. Compared to rodent models, NHPs exhibit greater genetic, immunological, and physiological similarities to humans, offering more predictive value for clinical outcomes.
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This brochure by Ace Therapeutics introduces the imiquimod-induced psoriasis mouse model, highlighting the complete modeling workflow, essential experimental data, and key readouts.
Model Features
- Clinical relevance: Replicates human psoriasis-like erythema, scaling, and epidermal hyperplasia.
- Immune response: Robust activation of the IL-23/IL-17 pathway, reflecting psoriasis mechanisms.
- Translatability: NHP immune system and skin structure better mimic human biology.
- Flexible applications: Suitable for topical, systemic, and biologic drug evaluation.
Applications
- Preclinical efficacy testing of novel small molecules and biologics
- Translational research bridging rodent data to human trials
- Dose optimization and biomarker validation
Why Choose Us?
- Comprehensive study design and customizable endpoints
- Integrated analyses: PASI-like scoring, histopathology, cytokine profiling, and immunophenotyping
- High-quality, reproducible data to support drug development pipelines
