Imiquimod-Induced Psoriasis Mouse Models
The imiquimod (IMQ)-induced psoriasis mouse model is one of the most widely used preclinical systems for studying psoriasis pathogenesis and evaluating novel therapeutics. By applying a topical imiquimod cream on the ear and back of mice, researchers at Ace Therapeutics can induce psoriasis-like lesions characterized by erythema, scaling, epidermal hyperplasia, and immune cell infiltration.
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This brochure by Ace Therapeutics introduces the imiquimod-induced psoriasis mouse model, highlighting the complete modeling workflow, essential experimental data, and key readouts.
Model Features
- Clinically relevant phenotype: Recapitulates key features of human plaque psoriasis.
- Immune responses: Strong activation of the IL-23/IL-17 pathway, resembling psoriasis mechanisms.
- Flexible applications: Suitable for drug efficacy evaluation, mechanism-of-action studies, and immunological research.
Applications in Drug Discovery
- Screening of topical and systemic anti-psoriatic drugs
- Evaluating anti-psoriatic drugs targeting IL-17/IL-23 pathways
- Investigating immune regulation in skin inflammation
Why Choose Us?
- Expertise in establishing psoriasis mouse models
- Customized study design and flexible dosing regimens
- Comprehensive readouts: PASI scoring, histopathology, cytokine profiling, and biomarker analysis
- Reliable results to accelerate your drug development pipeline
