Explore Vascular Cognitive Impairment Research With Our BCAS Model Case Study

BCAS is a widely used experimental model of cerebral small vessel disease (CSVD). At Ace Therapeutics, we provide customized BCAS models to help clients investigate the pathophysiological mechanisms underlying CSVD and develop novel therapeutics for vascular dementia.

• Detailed modeling procedure: Step-by-step description of the BCAS surgical method, including microcoil specifications and bilateral placement protocol to induce controlled cerebral hypoperfusion.
• Validated experimental data: Demonstrates significant cerebral blood flow reduction, white matter injury, and behavioral changes following chronic cerebral hypoperfusion.
• Comparative analysis: Highlights differences between control and BCAS groups, confirming the mode's reliability and reproducibility.

Comprehensive Readouts and Analytical Capabilities

• Cerebral blood flow (CBF) assessment: Laser Doppler flowmetry.
• Behavioral & cognitive tests: Morris water maze (MWM), Y-maze, open field test, rotarod test, etc.
• Histopathology: H&E and Nissl staining, immunohistochemistry (IHC).
• Imaging: MRI, PET-CT, etc.
• Molecular & biochemical assays: IgG leakage, Evans blue, PCR, western blotting.

Discover how Ace Therapeutics' BCAS model empowers researchers to explore thrombosis mechanisms and evaluate potential antithrombotic therapies.
Gain access to detailed methodologies, validation data, and representative results that can enhance the translational impact of your preclinical program.

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