In animals, specific gene expression profiles are found in brain tissue and blood after ischemic stroke. There are differences in RNA gene expression in the blood of stroke patients. Similar to protein profiles associated with ischemic stroke, gene profiles expressed in ischemic stroke have been identified as markers. RNA as a biomarker has advantages over protein, because RNA expression can be measured at the level of the entire transcriptome, which provides different molecular information than protein-level analysis. In addition, non-coding RNA can also be used as a biomarker for stroke. RNA biomarkers are expected to help diagnose stroke, determine the cause of the disease, and provide new insights into the mechanisms of stroke in patients.
Fig. 1. LncRNAs as biomarkers of stroke. (Fan et al., 2020)
Ace Therapeutics has years of experience in stroke biomarker development and offers comprehensive RNA biomarker screening, selection and validation services to accelerate your RNA biomarker program from early discovery to fully validated analysis.
A broad range of RNA biomarkers can be screened, and the relevant biomarkers can then be translated into focused panels and validated for your sample testing needs. Our team of experts is committed to assisting you with all your biomarker questions, and developing a customized approach to your RNA biomarker development program.
We perform gene expression analysis to quantify assess all genes expressed as RNA in cells, tissues or blood, helping our clients gain insight into the regulation of gene expression in stroke. Our scientists also use advanced gene chip technology to develop and validate a wide range of RNA biomarkers for pharmaceutical and biotechnology companies focused on stroke.
Type of RNA | Examples |
Messenger RNA (mRNA) | ARG1, LY96, MMP9, CCR7, INPP5D, ITA4, NAV1, CREM, PELI1, ZAK, CD46, CCL2, IL8, LAG3, HLA-DQA1 |
MicroRNA | Intracellular RNA: miR-122, miR-148a, let7i, miR-363, miR-19a, miR-320d, miR-4429, miR-363, miR-487b Extracellular RNA: miR-125a-5p, miR125b-5p, miR-143-3p |
Long Non-coding RNA (LncRNA) | lncRNA H19, lncRNA-ENST00000568297, lncRNA-ENST00000568243, lncRNA-NR_046084, lncRNA-linc-OBP2B-1 |
Circular RNA (circRNA) | circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, circRNA TLK1 |
We provide rapid, accurate, and cost-effective technologies to help clients detect RNA biomarkers in animal models of stroke.
With expertise in molecular biology and bioinformatics, Ace Therapeutics helps clients develop RNA biomarkers for stroke diagnosis and prediction of stroke cause. Please contact us for high-quality biomarker development services.
We are committed to accelerating progress in stroke research and drug development.