Single-photon Emission Computed Tomography (SPECT) Imaging Service in Animal Models of Stroke

Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are both radionuclide imaging techniques that allow assessment of localized cerebral blood flow and localized metabolic changes. SPECT records gamma rays directly after the emission of radionuclides, giving it a theoretical advantage over PET in terms of spatial resolution. SPECT also has the unique ability to image multiple probes labeled with different isotopes, allowing simultaneous study of multiple molecular or cellular events. SPECT imaging of cerebral blood flow, blood-brain barrier disruption, and apoptosis in rodents is now an effective tool for evaluating neuroprotective drugs and regenerative therapies against cerebral ischemia, as well as time windows for therapeutic interventions.

Fig. 1. SPECT imaging reveals early events of blood brain barrier (BBB) injury after experimental stroke. (Szigeti et al., 2015)

SPECT Imaging Service

Ace Therapeutics is at the forefront of providing SPECT imaging services for animal models of stroke. We use a dedicated SPECT system for small animal imaging to characterize the in vivo time profile of cerebral blood flow, blood-brain barrier disruption, and apoptosis following transient middle cerebral artery occlusion. Our experts have extensive experience in designing SPECT imaging protocols for small animals. We consider factors such as anesthesia, radioisotope selection, and imaging time points to ensure optimal imaging conditions and accurate data acquisition.

Ace Therapeutics offers customized radiolabeling and SPECT imaging with a variety of radionuclides.

[^99mTc] HMPAO for ischemic stroke brain perfusion SPECT imaging
[¹²³I] iomazenil for neuronal integrity SPECT imaging
[^99mTc] ECD for tissue viability SPECT imaging after stroke
[^99mTc]-HYNIC-annexin V for assessment of human cell stress and apoptosis SPECT imaging in an animal model of whole brain ischemia
[¹²⁵I]-CLINDE SPECT imaging of brain inflammation after cerebral ischemia
Customized SPECT radioisotopes for customer needs

We can combine SPECT imaging with CT imaging and PET imaging to generate quantitative data on the combination of stroke treatment compounds and brain function.

We can also combine PET imaging results with behavioral and biochemical readouts to provide translational preclinical data.

Applications of SPECT Imaging in Animal Models of Stroke

Study the mechanisms of stroke brain damage, such as cerebral blood flow, blood-brain barrier disruption, and apoptosis
Evaluate neuroprotective drugs for stroke
Evaluate regenerative therapies for cerebral ischemia
Develop diagnostic markers for stroke

Ace Therapeutics provides reliable SPECT imaging technology and radioisotopes to track and evaluate pathological changes in the brain following ischemic brain injury. We aim to accelerate your stroke research. If you are interested in our services, please do not hesitate to contact us!

Reference

Szigeti, K., et al. (2015). A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism, 35(12), 1921-1929.

All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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