Pathogenic Mechanism Analysis Services for Stroke

Most approved therapies for many diseases have been developed in response to their underlying pathophysiology. Therefore, understanding disease pathophysiology is critical to the successful development of clinically useful drugs. Ace Therapeutics specializes in the etiology and pathophysiology of stroke, including molecular and cellular changes. In addition, we can help you discover potential targets in the pathogenesis of stroke that have not yet been explored. Each study can be tailored to the client's needs.

Introduction to Stroke Pathophysiology

Stroke is the second leading cause of death and a major cause of disability worldwide. In stroke, disruption of cerebral blood flow leads to disruption of ATP synthesis and energy deprivation, as well as impaired ionic homeostasis and acid-base imbalance. All of these dysfunctions lead to neuropathological changes in the brain. Progress has been made in unraveling the pathogenesis and mechanisms of stroke, including cellular excitotoxicity, mitochondrial dysfunction, neuroinflammation, blood-brain barrier damage, and cell death processes. In addition, there are mechanistic links between cerebral ischemia, innate and adaptive immune cells, intracranial atherosclerosis, and gut microbiota in altering the brain's response to ischemic injury. Several signaling pathways are activated during these pathological transitions, and their targeted modulation may serve as a potential therapeutic strategy for stroke.

Fig. 1. Understanding the pathophysiology of stroke is key to successful drug development. Fig. 1. A brief summary for the pathophysiology involved in ischemic stroke. (Qin et al., 2022)

Our Services

Ace Therapeutics has a team of highly skilled scientists with extensive experience working closely with pharmaceutical companies to help them analyze the mechanisms of stroke pathology. Through our comprehensive analysis, we aim to help our clients improve their understanding of stroke pathophysiology, identify potential therapeutic targets for intervention, and develop stroke drugs that target different pathways of brain injury.

Stroke Pathogenesis Analysis

Ace Therapeutics utilizes well-established in vitro and animal models of stroke to study the complex pathophysiology of stroke. Our services include a comprehensive examination of the molecular changes and cellular responses associated with stroke pathology. We can analyze the cellular and molecular mechanisms involved in a wide range of stroke injuries and identify potential therapeutic targets.

Identification and Validation of Potential Therapeutic Targets for Stroke

Given the critical role that pathophysiology and signaling pathways play in ischemic stroke, we help clients identify and validate multiple potential therapeutic targets for stroke.

Pathological Mechanism of Stroke Targeting Key Signaling Pathways
  • GluN2B-PSD95-nNOS pathway
  • DAPK1 signaling pathway
  • PTEN-induced signaling pathway
  • AKT signaling pathway
  • Panx1 signaling pathway
Oxidative Stress
  • Nrf2/ARE signaling pathway
  • Sirtuin (SIRT)/forkhead box O (FOXO) signaling pathway
  • Chemokine-related signaling pathway
  • TLR-related signaling pathway
  • Cytokine-related signaling pathway
  • Sphingosine-1-Phosphate Signaling
Blood-Brain Barrier Damage
  • Sirt signaling pathway
  • MMP signaling pathway
Cell Death
  • Autophagy-related signaling pathway
  • Apoptosis-related signaling pathway
  • DNA methylation
  • Histone modification
  • Long non-coding RNAs

Our advanced neuroimaging techniques, molecular and cellular analyses, and animal models can help you elucidate the mechanisms of stroke pathophysiology and develop potential therapeutics for targeting key signaling pathways associated with stroke. When you need high-quality stroke mechanism research services, partner with Ace Therapeutics. Contact us today to discuss your project and learn how our expertise can contribute to your success.

  1. Qin, C., et al. (2022). Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal transduction and targeted therapy, 7(1), 215.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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