Apoptosis is a highly regulated, energy-dependent form of cell death. In contrast to necrosis, apoptosis deals with the dismantling of excess cells from the inside in an organized manner, thereby minimizing damage and destruction to neighboring cells. Many neurons in the ischemic hemidiaphragm or peri-infarct zone may undergo apoptosis after a few hours or days. There are two general pathways for the activation of apoptosis in stroke: the intrinsic pathway and the extrinsic pathway. Anti-apoptotic signaling restores dysfunctional neurons, whereas pro-apoptotic signaling leads to neuronal death, thus regulating the balance between pro- and anti-apoptotic signaling could be a potential therapeutic target.
Fig. 1. Signaling pathways of ischemia-induced apoptosis, including intrinsic (mitochondria-mediated), extrinsic (receptor-mediated), and caspase-independent pathways. (Zheng et al., 2003)
Ace Therapeutics' highly skilled team of experts with extensive experience in the field of stroke, provides reliable services to analyze the mechanisms of apoptosis after ischemic stroke and help clients discover anti-apoptotic signaling as a potential therapeutic target for stroke.
We use multifaceted approaches to study apoptotic mechanisms after cerebral ischemia. Our approach combines in vitro and in vivo models of ischemic stroke with advanced molecular and cellular techniques to help clients study the complex signaling pathways involved in apoptosis, including but not limited to:
Ace Therapeutics provides comprehensive molecular mechanism analysis services to help clients elucidate the key role of apoptosis in the pathogenesis of stroke. With leading analysis tools and rich collaboration experience, Ace Therapeutics can provide clients with high-quality experimental data to support their new drug development for stroke targeting apoptosis-related signaling pathways. If you are interested in our services, please do not hesitate to contact us!
We are committed to accelerating progress in stroke research and drug development.