Unlock Insights Into Stroke Research With Our FeCl₃ Induced Carotid Artery Thrombosis Model Case Study

At Ace Therapeutics, we provide advanced preclinical models to accelerate discovery in stroke and thrombosis drug development. Our FeCl₃-induced carotid artery thrombosis model is a validated platform that simulates oxidative vascular injury and thrombus formation, closely resembling human atherothrombotic events responsible for ischemic stroke.

What You'll Find Inside

• Detailed modeling procedure: Comprehensive step-by-step protocol outlining anesthesia, vessel exposure, FeCl3 application, occlusion induction, and post-surgical recovery.
• Model validation and reproducibility: Demonstrates a ~90% success rate and consistent infarct size (15-20%), confirming high model stability.
• Quantitative blood flow monitoring: Utilizes Laser Speckle Contrast Imaging (LSCI) and laser Doppler flowmetry to track real-time cerebral blood flow before and after thrombosis.
• Visual data and results: Includes representative imaging of pre- and post-occlusion conditions to illustrate thrombus formation and vascular changes.

Comprehensive Readouts and Analytical Capabilities

• Real-time thrombosis monitoring: In vivo microscopy, laser Doppler flowmetry, LSCI.
• Neurological scores and behavioral assessment: Neurologic deficit score, novel object recognition test, etc.
• Histopathology analysis: H&E staining, Masson's trichrome, Sirius red, immunohistochemistry (IHC).
• Hematological and coagulation markers: Hematology, coagulation parameters, inflammatory biomarker.
• Protein and molecular analyses: Western blotting, PCR, and multiplex cytokine profiling.

Our preclinical models are designed with flexibility to meet the diverse needs of neuroscience researchers and pharmaceutical developers. By downloading this case study, you'll see how our FeCl₃-induced carotid artery thrombosis model can accelerate your stroke research and strengthen the translational impact of your therapeutic programs.

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