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Neuroprotective Efficacy of Edaravone in a Rat tMCAO Model

The objective of this study was to establish a rat tMCAO model and to evaluate the neuroprotective efficacy of Edaravone following transient focal cerebral ischemia. Functional, neurological, and histopathological outcomes were assessed to characterize treatment effects and model reliability.
Case Studies

Accelerate Stroke Therapeutic Development with the Rat tMCAO Model

The transient middle cerebral artery occlusion (tMCAO) model is considered the gold standard preclinical model for ischemic stroke research, providing a robust platform for evaluating neuroprotective and neurorestorative therapies.

This case study highlights the neuroprotective activity of Edaravone following focal cerebral ischemia and reperfusion, demonstrating measurable improvements across multiple efficacy endpoints.

Download this case study to see:

  • A validated transient MCAO (tMCAO) stroke model
  • Neuroprotective efficacy data for Edaravone
  • Quantitative infarct volume assessment
  • Neurological and behavioral outcome measurements
  • Translationally relevant study design and readouts

Download the case study to discover how our preclinical stroke models can support your therapeutic development programs.