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Overview of Collagenase-Induced Intracerebral Hemorrhage (ICH) Model

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Overview of Collagenase-Induced Intracerebral Hemorrhage (ICH) Model

The collagenase-induced ICH model reliably reproduces key pathological features, including microvascular rupture, mixed parenchymal hemorrhage, inflammation, and brain edema, providing a robust platform for studying ICH mechanisms and evaluating therapeutic strategies.
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Unlock Insights into Stroke Research | Specialized Experimental Model Solutions

Ace Therapeutics' Collagenase-Induced ICH Model offers a robust, reproducible, and pathophysiologically relevant platform to accelerate preclinical ICH research and therapeutic development. This brochure provides a comprehensive overview of our collagenase-induced ICH model, detailing how it supports mechanistic studies and translational drug evaluation across multiple stages of hemorrhagic stroke research.

A Gold-Standard Model for Hemorrhagic Stroke

  • Progressive hematoma formation that more closely mimics spontaneous human ICH than whole-blood injection models
  • Highly reproducible lesion size and location, enabling consistent and interpretable outcomes
  • Tunable injury severity, allowing modeling of mild to severe hemorrhage through collagenase dose adjustment .

Capturing Secondary Brain Injury Mechanisms

  • Robust perihematomal edema and neuroinflammatory responses
  • Modeling of ischemic penumbra and secondary tissue damage
  • Ideal for evaluating neuroprotective, anti-inflammatory, and edema-reducing therapies

Comprehensive Functional and Pathological Readouts

  • Neurological and behavioral assessments to quantify functional impairment
  • Sensorimotor tests including placement and corner turn assays
  • Brain water content analysis for objective measurement of cerebral edema

Designed for Translational ICH Drug Development

Ace Therapeutics' collagenase-induced ICH model supports a wide range of research and development objectives, including:

  • Pathogenesis and mechanism-of-action studies in hemorrhagic stroke
  • Preclinical efficacy testing of small molecules, biologics, and cell-based therapies
  • Investigation of post-ICH inflammation, edema, and multi-organ dysfunction

Discover how the Ace Therapeutics Collagenase-Induced ICH Model can help you generate meaningful, decision-driving preclinical data in hemorrhagic stroke research.

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