Unlock Insights into Stroke Research | Specialized Experimental Model Solutions

Given the poor translational success of rodent models and the close similarities between NHPs and humans in cerebrovascular anatomy, neuroanatomy, and molecular biology, NHPs are regarded as the most suitable preclinical models for translational stroke research.

At Ace Therapeutics, we provide a comprehensive portfolio of customized NHP ischemic stroke models designed to help our clients de-risk development, validate efficacy, and strengthen clinical relevance at critical preclinical milestones.

Why Download This Brochure?

This brochure provides an practical overview of Ace Therapeutics' NHP stroke modeling capabilities. Inside, you will discover:

High-Translational-Relevance NHP Models

• Replication of human-like cerebral vasculature, gray/white matter composition, and immune responses
• Stroke induction strategies that model acute, subacute, and recovery phases of ischemic injury

Multiple Clinically Relevant Stroke Induction Approaches

• Endothelin-1 (ET-1)–induced MCAO with stereotaxic precision
• Endovascular catheter-based MCA occlusion and reperfusion
• Craniotomy-induced MCA electrocoagulation and clipping
• DSA-guided autologous thrombus models enabling ultra-acute intervention studies

Multimodal Imaging and Functional Readouts

• MRI (DWI, T2-FLAIR), CTA, CTP, and MRA for lesion evolution and reperfusion analysis
• Quantitative infarct volume assessment and cerebral blood flow monitoring
• Neurological scoring systems and fine motor and behavioral task batteries to capture functional recovery

Explore how Ace Therapeutics' NHP ischemic stroke models can elevate your preclinical strategy, reduce translational risk, and accelerate your path to the clinic.

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