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129S6/SvEv- Liastm1Mae /J
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129S6/SvEv- Liastm1Mae /J

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Cat. No.: DMM-001288

Status Age Sex
  • Live Mouse
  • Frozen Embryo
  • 4 weeks
  • 12 weeks
  • Customized Age
  • Male
  • Female
Model Overview
Model Description This Liastm1Mae mutant allele has the exons 4-6 of the of the lipoic acid synthetase (Lias) gene deleted. The deleted region encodes the functionally conserved Cys motifs of the enzyme responsible for converting octanoic acid to α-lipoic acid (also called 1,2-dithiolane-3-pentanoic acid, thioctic acid, ALA, or LA). These Lias mutant mice may be useful in studying α-lipoic acid requirements during development, mitochondrial dysfunction, and oxidative stress-related diseases such as diabetes, atherosclerosis, and neurodegenerative disorders.
Strain Name 129S6/SvEv-Liastm1Mae/J
Background Strain 129S6 / SvEv
SPF Yes
Research Application Diabetes
Target Information
Target Name LIAS
Synonyms 2900022L22Rik, 4933425M12Rik, 7a5ex, HGCLAS, HUSSY-01, LAS, LIP1, LS, MGC7254, mLip1, PDHLD
Gene ID 11019
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