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Cat. No.: DMM-001254
| Status | Age | Sex |
|---|---|---|
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| Model Overview | |
|---|---|
| Model Description | ALS/LtJ and ALR/LtJ inbred strains are useful for a wide range od studies including type 1 and type 2 diabetes, obesity, metabolism and toxicology research. Treatment of alloxan or streptozotocin causing pancreatic beta cell destruction, leads to severe hyperglycemia and hypoinsulinemia in ALS/LtJ mice. Alloxan-untreated ALS/Lt males exhibit impaired glucose tolerance when tested by intraperitoneal administration of glucose, and become hyperinsulinemic. ALS/LtJ mice contain genes predisposing to both experimentally-induced type 1 and spontaneously-developing type 2 diabetes mellitus. ALS/Lt mice exhibit significantly lower antioxidant defenses than do ALR/Lt. ALS/Lt is a useful control strain for comparing inbred strain susceptibility to free radical-mediated damage. |
| Strain Name | ALS/LtJ |
| Background Strain | ALS/Lt and ALR/Lt |
| SPF | Yes |
| Research Application | Diabetes |
| Target Information | |
|---|---|
| Target Name | Cdh23; Gnat2; mt-Tr |
| Synonyms | 4930542A03Rik, ahl, bob, CDHR23, mdfw, nmf112, nmf181, nmf252, PITA5, sals, USH1D; ACHM4, Gnat-2, GNATC, Gt-2, HG1D, Tcalpha; MTTR, tRNA, tRNA-Arg, TrnR tRNA |
| Gene ID | 64072; 2780; 4573 |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
