B6.129S4- Insr^tm1Dac /J

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B6.129S4- Insr^tm1Dac /J

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B6.129S4- Insr^tm1Dac /J

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Cat. No.: DMM-001265

Status	Age	Sex
Live Mouse Frozen Embryo	4 weeks 12 weeks Customized Age	Male Female

Model Overview
Model Description	Mice carrying two copies of the Insrtm1Dac mutation (homozygotes) die within 48-72 hours after birth from diabetic keto-acidosis, characterized by fatal weight loss through dehydration and protein wasting. Although embryonic development proceeds normally with no obvious anatomical defects, heterozygous carriers display mild insulin resistance.
Strain Name	B6.129S4-Insrtm1Dac/J
Background Strain	129S4/SvJae
SPF	Yes
Research Application	Diabetes

Target Information
Target Name	Insr
Synonyms	4932439J01Rik, CD220, D630014A15Rik, HHF5, IR, IR-A, IR-B
Gene ID	3643

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.

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