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B6;SJL-Tg（aP2-SREBF1c）9884Reh/J
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B6;SJL-Tg（aP2-SREBF1c）9884Reh/J

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Cat. No.: DMM-001252

Status Age Sex
  • Live Mouse
  • Frozen Embryo
  • 4 weeks
  • 12 weeks
  • Customized Age
  • Male
  • Female
Model Overview
Model Description This transgenic mouse model recapitulates human congenital generalized lipodystrophy (CGL) through adipose tissue-specific overexpression of SREBP-1c, which leads to the core characteristics of CGL: a near absence of adipose tissue, severe insulin resistance, and consequent type II diabetes and fatty liver.
Strain Name B6;SJL-Tg(aP2-SREBF1c)9884Reh/J
Background Strain (C57BL/6J x SJL)F2
SPF Yes
Research Application Diabetes
Target Information
Target Name transgene insertion 9884
Synonyms aP2-SREBP-1c436
Gene ID -
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