Cat. No.: DMM-001287
| Status | Age | Sex |
|---|---|---|
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| Model Overview | |
|---|---|
| Model Description | These mice carry a spontaneous mutation at the Lepr locus on a C57BLKS/J background and are characterized by obesity, elevation of blood sugar, depletion of insulin-producing beta-cells of the pancreatic islets, and early death. The strain carries the misty mutation (Dock7m) to aid in early identification of homozygotes. |
| Strain Name | BKS.Cg-Dock7m Leprdb/+ +/J |
| Background Strain | DBA/J |
| SPF | Yes |
| Research Application | Diabetes |
| Target Information | |
|---|---|
| Target Name | Dock7; Lepr |
| Synonyms | 3110056M06Rik, DEE23, EIEE23, LOC242555, m, mKIAA1771, ZIR2; CD295, Fa, LEP-R, Leprb, LEPRD, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-R, OB-RGRP |
| Gene ID | 85440; 3953 |
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