Cat. No.: DMM-001257
Status | Age | Sex |
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Model Overview | |
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Model Description | These mice carry a spontaneous mutation at the Lep locus on a C57BLKS/J background and are characterized by obesity, hyperphagia, hyperglycemia, glucose intolerance, and elevated plasma insulin. On the C57BLKS background homozygotes become severely diabetic with regression of islets and early death. |
Strain Name | BKS.Cg-Lepob/J |
Background Strain | C57BLKS/J |
SPF | Yes |
Research Application | Diabetes |
Target Information | |
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Target Name | Lep |
Synonyms | LEPD, OB, obese, OBS |
Gene ID | 3952 |
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