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C57BL/6N-Tg(Ins2-Chrm3*)QJwe/J
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C57BL/6N-Tg(Ins2-Chrm3*)QJwe/J

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Cat. No.: DMM-001286

Status Age Sex
  • Live Mouse
  • Frozen Embryo
  • 4 weeks
  • 12 weeks
  • Customized Age
  • Male
  • Female
Model Overview
Model Description These β-rhM3Dq Tg (or β-R-q Tg) mice express the G protein-coupled receptor DREADD rhM3Dq (also called R-q) directed to pancreatic β-cells by the rat insulin 2 promoter. rhM3Dq induces the canonical G q/11 signaling pathway specifically following administration of the pharmacologically inert molecule clozapine- N -oxide (CNO). These mice may be useful for chemogenetic/pharmacogenetic applications to express an activating DREADD for studying G protein regulation of β-cell function.
Strain Name C57BL/6N-TG（Ins2-Chrm3*）QJwe/J
Background Strain C57BL/6NTac
SPF Yes
Research Application Diabetes
Target Information
Target Name Tg（Ins2-Chrm3*）QJwe
Synonyms transgene insertion Q, Jurgen Wess
Gene ID -
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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