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C57BL/6N-Tg(Ins2-Chrm3*)SJwe/J
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C57BL/6N-Tg(Ins2-Chrm3*)SJwe/J

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Cat. No.: DMM-001297

Status Age Sex
  • Live Mouse
  • Frozen Embryo
  • 4 weeks
  • 12 weeks
  • Customized Age
  • Male
  • Female
Model Overview
Model Description These β-GsD Tg (or β-R-s Tg) mice express the G protein-coupled receptor DREADD GsD (also called rM3Ds or R-s) directed to pancreatic β-cells by the rat insulin 2 promoter. GsD induces the canonical Gα s signaling pathway specifically following administration of the pharmacologically inert molecule clozapine- N -oxide (CNO). These mice may be useful for chemogenetic/pharmacogenetic applications to express an activating DREADD for studying G protein regulation of β-cell function.
Strain Name C57BL/6N-TG（Ins2-Chrm3*）SJwe/J
Background Strain C57BL/6NTac
SPF Yes
Research Application Diabetes
Target Information
Target Name transgene insertion S
Synonyms -
Gene ID -
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