This brochure provides a detailed overview of our high-fat diet combined with low-dose streptozotocin (HFD/STZ)-induced diabetic nephropathy (DN) model, designed to support preclinical research into diabetic complications.

What You'll Find Inside

• Modeling Methods & Features: Rodents are fed a high-fat diet for 4–6 weeks, followed by a low-dose STZ injection, with continued HFD feeding for another 4–8 weeks. This induces stable hyperglycemia, proteinuria, and glomerular injury.
• Key Endpoints: Includes body weight, fasting blood glucose levels, and urinary protein/creatinine ratios with statistical comparisons.
• Customizable Services: Beyond the parameters shown in the brochure, we can also provide customized diabetic nephropathy models and key readout assays based on client’s specific drug targets and research needs.

This model plays a crucial role in elucidating disease pathogenesis, exploring therapeutic strategies, and developing pharmacological interventions.

Please download the brochure for complete diabetic nephropathy modeling methods, key readout assays, and representative data. Our preclinical experts will contact you to discuss how this model can be customized and integrated into your diabetes drug discovery projects.

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