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Cat. No.: DMM-001270
| Status | Age | Sex |
|---|---|---|
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| Model Overview | |
|---|---|
| Model Description | These mice carry the retinal degeneration (Pde6b) mutation and exhibit certain tendencies toward autoimmune disease. A low plasma insulin level is characteristic. Immunologic abnormalities include perivascular/periductular leukocyte infiltration into the pancreas and submandibular salivary glands, and T lymphocytopenia in spleen. Both males and females show early impaired glucose tolerance, development of moderate mature-onset obesity in the presence of low plasma insulin levels, and development of glomerulosclerotic kidney lesions. This strain is useful as a model for type 2 (NIDDM) diabetes. |
| Strain Name | NON/ShiLtJ |
| Background Strain | various |
| SPF | Yes |
| Research Application | Diabetes |
| Target Information | |
|---|---|
| Target Name | Pde6b |
| Synonyms | CSNB3, CSNBAD2, GMP-PDEbeta, nmf137, PDEB, r, rd, rd1, rd10, RP40 |
| Gene ID | 5158 |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
