Unlock Insights into Stroke Research | Specialized Experimental Model Solutions

Understanding how drugs and biologics cross the blood-brain barrier (BBB) is one of the greatest challenges in developing effective stroke therapies. At Ace Therapeutics, we provide customized in vitro BBB models to support our clients in investigating the pathophysiological mechanisms of the BBB in stroke and advancing the development of novel therapeutics for ischemic brain injury.

Why Our In Vitro BBB Models Stand Out

Our models combine primary endothelial and glial co-culture systems to simulate the structural and functional integrity of the BBB under both normal and ischemic conditions. Each model is meticulously optimized for stroke research applications, enabling the study of:

• Cell viability and apoptosis under oxidative or ischemic stress
• Barrier integrity through transendothelial electrical resistance (TEER) and permeability assays
• Endothelial-glial interactions using high-resolution confocal microscopy
• Molecular characterization of key tight junction proteins such as claudin-5, occludin, and ZO-1

Whether you are screening novel neuroprotective compounds or evaluating BBB permeability, our models deliver reproducible data to accelerate the discovery and development of stroke drugs.

Applications Across Preclinical Stroke Research

Our in vitro BBB platforms are ideal for:

• Drug screening and efficacy validation
• Mechanistic studies on endothelial and glial dynamics
• Evaluation of therapeutic transport across the BBB
• Ischemic reperfusion injury modeling

Accelerate Your Path to Discovery

Partner with Ace Therapeutics to access reliable, validated in vitro BBB models specifically designed for stroke research.

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