logo

Pharmacological Study of Edaravone Treatment in Collagenase-Induced ICH Mouse Model

The objective of this study was to evaluate the neuroprotective efficacy of edaravone in a collagenase-induced intracerebral hemorrhage (ICH) mouse model by assessing its effects on neurological function, hemorrhage volume, and cerebral edema.
Case Studies

Advance Intracerebral Hemorrhage Research with a Validated Collagenase-Induced ICH Model

Intracerebral hemorrhage (ICH) accounts for a relatively small proportion of stroke cases but is responsible for a disproportionately high burden of mortality and long-term disability. Robust preclinical models are essential for evaluating novel interventions and understanding the mechanisms of secondary brain injury.

Our collagenase-induced ICH mouse model reproduces critical pathological events, including vascular disruption, hematoma expansion, neuroinflammation, and cerebral edema, providing a powerful platform for therapeutic evaluation.

Download this case study to see:

  • A robust and reproducible collagenase-induced ICH model
  • Neuroprotective efficacy data for Edaravone treatment
  • Functional recovery assessed by neurological scoring
  • Quantitative measurements of hematoma volume and brain edema
  • Translational endpoints relevant to clinical development

Download the case study to explore how our ICH research platform can support the development of stroke therapeutics.