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B6.129S6- Mapk8ip1tm2.1Rjd /J
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B6.129S6- Mapk8ip1tm2.1Rjd /J

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Cat. No.: DMM-001263

Status Age Sex
  • Live Mouse
  • Frozen Embryo
  • 4 weeks
  • 12 weeks
  • Customized Age
  • Male
  • Female
Model Overview
Model Description Serine 59 of the Mapk8ip1 (mitogen-activated protein kinase 8 interacting protein 1) gene is replaced with an asparagine, to correspond with a human polymorphism associated with type 2 diabetes. Feeding homozygous mice a high-fat diet causes a reproducible, but modest, reduction in JNK (Mapk8, mitogen-activated protein kinase 8) activation, but does not increase the susceptibility of mice to diet-induced obesity or insulin resistance.
Strain Name B6.129S6-Mapk8ip1tm2.1Rjd/J
Background Strain 129S6/SvEvTac
SPF Yes
Research Application Diabetes
Target Information
Target Name Mapk8ip1
Synonyms IB1, Jip1, Jip-1, Mapk8ip, MAPK8IP1, mjip-2a, PRKM8IP, Skip
Gene ID 9479
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