UNx combined with STZ-Induced Diabetic Nephropathy Model in CD1 Mice

Diabetic nephropathy (DN) requires robust preclinical models that mimic both renal injury and metabolic disorders. Our case study details a surgical-chemical DN model in CD1 mice (UNx + low-dose STZ).

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This well-characterized DN model provides a robust experimental platform for evaluating antidiabetic nephropathy candidates, supporting your drug development program with validated, reproducible data.

This promotional material will provide you with a detailed presentation of:

Complete experimental design: A clear overview of the study protocol, including animal grouping, UNx surgical procedure, STZ induction regimen, and endpoint measurements.
Comprehensive endpoint data: Quantitative results including body weight, fasting blood glucose levels, 24-hour urine volume, urinary albumin-to-creatinine ratio (UACR), serum potassium ion levels, and serum creatinine levels at the experimental endpoint.
Histopathological evidence: HE and PAS staining results, providing visual confirmation of renal tissue damage and pathological changes.

Download the case study to access complete experimental parameters, raw data outputs, and histopathological images. Then contact us to discuss how this model can be tailored to your DN drug evaluation program.

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UNx combined with STZ-Induced Diabetic Nephropathy Model in CD1 Mice

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