Customized In Vivo Ocular Models ace

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- By Disease

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* Services of Interest: Customized Animal Models of Retinal Degeneration
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* All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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Customized Animal Models of Retinal Degeneration

Ace Therapeutics is committed to providing customized retinal degeneration animal model development and comprehensive evaluation services to support target validation, candidate prioritization, and rigorous efficacy and tolerability assessment. Designed for ophthalmic research needs, our services combine tailored animal models with reliable data to enable therapeutic discovery and preclinical characterization with high consistency and strong translational relevance.

Overview of Retinal Degeneration

Retinal degeneration describes a group of disorders that share progressive damage and loss of the neurovascular retina. Major categories include photoreceptor and retinal pigment epithelium (RPE) dystrophies, retinal ganglion cell (RGC) and optic nerve degeneration, and neurovascular injury such as diabetic retinopathy (DR) and other ischemic retinopathies. Different triggers, such as genetic defects, metabolic stress, ischemia, or toxic exposure, activate similar pathogenic cascades. Oxidative and metabolic stress, mitochondrial dysfunction, protein misfolding, excitotoxicity, and chronic inflammation injure neurons, glia, and vascular cells, disturb retinal layering and synaptic function, and finally impair visual signal processing.

Fig. 1. Current and upcoming treatment approaches for rescuing retinal degeneration-associated vision loss. Fig. 1. Current and future treatment strategies for rescuing vision loss due to retinal degeneration. (Majidi S, et al., 2021)

Explore Our Animal Models of Retinal Degeneration

Our scientists specialize in developing customized animal models of retinal degeneration, tailored to align with specific research programs targeting defined genetic mutations, pathogenic pathways, or characteristic disease phenotypes. Our retinal degeneration models are well-established and validated to recapitulate relevant retinal structural changes, characteristic patterns of cellular loss, and associated functional impairment in alignment with each program's scientific objectives. Through close collaboration with our clients, we refine key parameters, including species selection and overall study design, to ensure that disease onset, severity, and progression are appropriate for the intended preclinical application.

Retinal Degeneration Animal Model Evaluation Services

We provide dedicated retinal degeneration animal model preclinical evaluation services centered on quantitative, reproducible endpoints. Within integrated preclinical study designs, we evaluate structural changes, functional deficits, and molecular responses in retinal degeneration models, generating coherent data sets that support the preclinical development of ophthalmic small-molecule drugs, biologics, gene therapies, and cell therapies.

Service Category	Available Services
Retinal Structural Imaging	Optical coherence tomography (OCT) for non-invasive visualization of retinal layer thickness and structural integrity, enabling longitudinal tracking of degenerative changes.
Functional Assessment	Electroretinography (ERG) to assess retinal electrical activity, including rod and cone responses.
Molecular & Histological Analysis	Gene expression profiling (RT-PCR, RNA sequencing), protein analysis (Western blot, immunohistochemistry), and cellular staining (TUNEL, immunofluorescence) to quantify cell death, inflammatory activation, and pathway modulation.
Vascular & Tissue Imaging	Fluorescein angiography and confocal microscopy to assess retinal vasculature integrity, neovascularization, and tissue remodeling.

Ace Therapeutics offers retinal degeneration animal model customization services and comprehensive evaluation support to address diverse preclinical objectives, from mechanistic studies and target validation to rigorous efficacy evaluation and candidate selection. Contact us to discuss your retinal degeneration research needs and explore how we can support your next steps in preclinical development.

References

Rosa JGS, Rosa GR, Pinto FJ, et al. Revisiting Retinal Degeneration Hallmarks: Insights from Molecular Markers and Therapy Perspectives. Int J Mol Sci. 2023 Aug 23; 24(17): 13079.
Kovács-Öller T, Völgyi B. Molecular Mechanisms of Retinal Degeneration and How to Avoid It. Int J Mol Sci. 2023 May 15; 24(10): 8752.
Majidi S, Ogilvie JM, Flaveny CA. Retinal Degeneration: Short-Term Options and Long-Term Vision for Future Therapy. Mo Med. 2021 Sep-Oct; 118(5): 466-472.

For Research Use Only.