Customized In Vivo Ocular Models ace

- By Animal Species
- By Disease

Get in Touch ace

* First Name:
* Last Name:
* Business Email:
Phone:
Company/Institution:
Job Title:
* Services of Interest: Customized Animal Models of Retinal Detachment
When do you expect your project to start?
Project Description:
* All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
* Tick to confirm the Research Use Only (RUO) statement.

Customized Animal Models of Retinal Detachment

As a research service provider, Ace Therapeutics is dedicated to developing customized animal models of retinal detachment (RD) to support preclinical studies of mechanism, efficacy, and delivery for neuroprotective and antifibrotic therapeutics, as well as gene- and cell-based therapies. We offer flexible, well-characterized in vivo and ex vivo platforms that enable early discovery, candidate selection, dose and regimen refinement, and longitudinal assessment across a wide range of preclinical study designs.

Pathophysiology of Retinal Detachment

RD is a sight-threatening condition defined as separation of the neurosensory retina from the retinal pigment epithelium, disrupting photoreceptor support and leading to rapid cell death and structural remodeling. Mechanistically, RD is commonly classified into rhegmatogenous, tractional, and exudative forms, according to the presence of retinal breaks, traction from fibrocellular or neovascular membranes, or subretinal fluid accumulation without a tear. Preclinical animal models of RD that recapitulate these key pathogenic mechanisms provide a controlled setting to interrogate disease pathways and to evaluate emerging therapeutic strategies.

Fig. 1. Three primary types of retinal detachment. Fig. 1. The three major forms of retinal detachment. (A) Rhegmatogenous retinal detachment with a retinal break. (B) Traction retinal detachment with vitreoretinal tractional forces. (C) Exudative retinal detachment without traction or retinal breaks. (Zhang ZY, et al., 2021)

Explore Our Animal Models of Retinal Detachment

Our preclinical RD model platform integrates multiple species, induction methods, and disease time courses into a flexible framework that can be aligned with different targets, modalities, and development stages. The portfolio spans acute and chronic RD, focal and more extensive detachments, and variable durations and severities, enabling study designs that range from short-term mechanism exploration to long-term structural and functional follow-up. Our RD models provide a versatile platform for evaluating a broad spectrum of retinal drug candidates, biologics, delivery systems, and ophthalmic devices, supporting researchers throughout preclinical research.

Retinal Detachment Animal Model Evaluation Services

Ace Therapeutics provides a comprehensive suite of ophthalmic imaging, functional testing, and tissue analysis services to support your preclinical retinal detachment studies.

Service Category	Available Services
In Vivo Structural Imaging	Color fundus photography to document RD extent, hemorrhage, fibrosis, and neovascularization. Optical coherence tomography (OCT) to visualize retinal structure, detachment height, and subretinal fluid. Fluorescein angiography (FA) to assess retinal vascular leakage and perfusion status. Fundus autofluorescence (FAF) to assess retinal pigment epithelium changes and outer retinal integrity.
Functional Evaluation	Electroretinography (ERG) to assess global retinal electrophysiological function in RD models. Optokinetic tracking (OKT) to provide behavioral readouts of visual function.
Tissue Analysis and Molecular Profiling	H&E staining to evaluate overall retinal morphology and layer organization. Immunohistochemistry (IHC) and immunofluorescence to localize photoreceptors, glial activation, microglial response, and cell death or stress markers. TUNEL assay to quantify apoptotic cell death. qPCR, Western blot, and multiplex immunoassays to profile gene and protein expression associated with inflammation, stress responses, and tissue remodeling.

At Ace Therapeutics, our customized animal models of RD are integrated with the ocular technology platform to support preclinical retinal disease studies. Our scientific team can work with you to ensure that study design and key experimental considerations are closely aligned with your specific preclinical research objectives. Please contact us to discuss how our RD models can support your preclinical retinal detachment program.

References

Xiong J, Tran T, Waldstein S, et al. A review of rhegmatogenous retinal detachment: past, present and future. Wien Med Wochenschr. 2025 May; 175(7-8): 186-202.
Zhang ZY, Sun YJ, Song JY, et al. Experimental models and examination methods of retinal detachment. Brain Res Bull. 2021 Apr; 169: 51-62.
Kwok JM, Yu CW, Christakis PG. Retinal detachment. CMAJ. 2020 Mar 23; 192(12): E312.

For Research Use Only.