At Ace Therapeutics, our scientists integrate validated ocular electrophysiology endpoints into our customized in vivo animal models of ophthalmic diseases to objectively quantify retinal and optic nerve function, supporting efficacy, safety, and mechanism-of-action evaluations for your compounds of interest in preclinical studies. As part of our end-to-end service offerings, electrophysiology assessments can be incorporated as needed throughout the workflow, from model development to longitudinal follow-up and data interpretation.

Why Ocular Electrophysiology Matters in Preclinical Research

Ocular electrophysiology provides objective, quantitative functional readouts across the visual system, supporting sensitive assessment of retinal and optic nerve integrity in preclinical ophthalmic research. By capturing stimulus-evoked electrical responses, these assays complement imaging and histopathology with direct measures of neural function and can help localize dysfunction across retinal pathways and layers. With non-invasive, repeatable recordings, electrophysiology is well suited for longitudinal study designs, facilitating robust comparisons across time points, dose levels, and study groups within animal models of ophthalmic diseases.

Fig. 1. Trace map of the full-field retinography and flash VEPs in all cynomolgus monkeys. (Choi KE, et al., 2021)

Our Preclinical Ocular Electrophysiology Capabilities

Our electrophysiology capabilities are built for preclinical ophthalmology studies that require reliable functional endpoints in disease-relevant animal models. We tailor our assessment approach to your specific biological target of interest and study objectives, applying standardized recording conditions and analysis methods to deliver consistent, interpretable results. Whether you need broad retinal function screening, pathway-specific localization, or sensitive readouts for neuroprotection, our team integrates electrophysiology into your study, alongside model induction, dosing, and complementary endpoints to strengthen pharmacology packages and mechanistic understanding.

Full-Field Electroretinography

Our team performs full-field electroretinography at scheduled study timepoints to quantify global retinal function and track functional change over days to months in animal models of ophthalmic diseases.

Multifocal Electroretinography

When region-specific readouts are needed, we can incorporate multifocal electroretinography to deliver localized retinal function data. This enables you to monitor regional responses and detect spatially confined effects in focal phenotypes or localized delivery studies.

Pattern Electroretinography

When RGC-focused functional sensitivity is a priority, we add pattern electroretinography to the in vivo assessment plan to strengthen longitudinal efficacy readouts and support mechanism-driven interpretation in relevant ophthalmic disease models.

Photopic Negative Response

Our team incorporates photopic negative response into glaucoma and optic neuropathy studies to track retinal ganglion cell (RGC) function over time and quantify functional preservation or decline as part of your efficacy and mechanism package.

Visual Evoked Potentials

For programs requiring functional assessment beyond retinal endpoints, we offer visual evoked potentials (VEP) to evaluate visual pathway integrity. This enables you to contextualize findings in models involving the optic nerve or addressing downstream signaling pathways.

How Our Electrophysiology Services Support Your Preclinical Ophthalmology Program

• Quantify functional changes over time in ophthalmic disease animal models to support efficacy assessment and dose-response evaluation.
• Add sensitive functional readouts for glaucoma and optic neuropathy studies to support neuroprotection-focused research.
• Strengthen mechanistic interpretation by pairing functional signals with complementary structural endpoints within the same model.
• Capture region-specific or pathway-level effects when needed, supporting focal phenotypes, localized drug delivery studies, and optic nerve-involved models.

To incorporate objective functional endpoints into your preclinical ophthalmology study, Ace Therapeutics offers integrated ocular electrophysiology within customized disease models. Our approach supports your efficacy assessment and mechanistic characterization. Please contact us to discuss your biological target, model requirements, and preferred functional endpoints.

References

1. Choi KE, Anh VTQ, Yun C, et al. Normative Data of Ocular Biometry, Optical Coherence Tomography, and Electrophysiology Conducted for Cynomolgus Macaque Monkeys. Transl Vis Sci Technol. 2021 Nov 1; 10(13): 14.
2. Karanjia R, Coupland SG. Electrophysiology in neuro-ophthalmology. Adv Ophthalmol Optom. 2019 Aug; 4: 245-257.

• Ocular Pharmacology Services
• Ocular Pharmacokinetic Services
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• Ocular Toxicology Services
• Ocular Biomarker Services
• Ocular Biospecimen Services
• Customized Non-GLP Ophthalmic Program Development Services
• Customized Services for Ocular Drug Delivery System Development
• Preclinical Ophthalmic Imaging Services
• Preclinical Intraocular Pressure Measurement Services
• Visual Function Behavioral Testing Services
• Ocular Resolution Pharmacology and SPM Services