Organ-on-a-Chip BBB Models

BBB-on-a-chip aims to recreate a functional human BBB with appropriate 3D spatial arrangement of cells, intercellular communication, and organ-specific mechanical and biochemical gradients. At Ace Therapeutics, we offer several organ-on-a-chip BBB models that provide a realistic representation of the BBB, allowing you to study drug transport across the barrier, evaluate the efficacy of drug candidates, and investigate the mechanisms of neurodegenerative diseases.

With our BBB organ-on-a-chip models, you can evaluate the permeability of drugs across the barrier, assess drug efficacy, and study the impact of various factors on the BBB function. This technology offers a more cost-effective and time-efficient alternative to traditional animal models and static cell culture systems.

What Is Organ-on-a-Chip?

An organ chip, a new type of biomedical device, is an artificial organ model developed based on microfluidic technology and biochip technology. It uses tiny chips or biological materials to build structures that simulate real organs, and studies and observes organ functions and reactions by simulating physiological functions and physiological environments. These have been used to overcome the limitations of traditional in vitro models.

Organ-on-a-Chip BBB Models

For BBB researchs, traditional in vitro models rely on Petri dishes or Transwell systems. However, these static models lack necessary microenvironmental factors such as shear stress and appropriate cell-cell interactions. Organ-on-a-chip BBB models are bioengineered devices that mimic the structure and function of the human BBB to better recreate the highly dynamic in vivo human brain microenvironment known as the neurovascular unit (NVU).

Fig. 1. 3D spheroid models of the BBB. (Cui B, et al., 2022)

Please choose from our organ-on-a-chip BBB kits to build 3D BBB or BBB-related organ disease models!

1. Cui B, Cho SW. Blood-brain barrier-on-a-chip for brain disease modeling and drug testing. BMB Rep. 2022, 55(5):213-219.