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Bovine Brain Microvascular Endothelial Cells
Cat.#: BBM-C-130
Specifications
| Source | Brain |
| Disease | Normal |
| Species | Bovine |
| Cell Type | Endothelial |
| Description | Bovine Brain Microvascular Endothelial Cells (BBMVEC) from Ace Therapeutics are isolated from microvessels of the bovine brain. The cells are cryopreserved at the second passage. |
| Applications | The Bovine Brain Microvascular Endothelial Cells (BBMVEC), a model for studying the blood-brain barrier (BBB), allows researchers to investigate the transport of drugs across the blood-brain barrier, examine brain endothelial cell tight junctions, and explore the basic biology of brain microvascular endothelial cells more effectively. The endothelial cells in this system exhibit tight junctions (positive for proteins ZO-1 and Claudin-1) and have transport characteristics similar to those found in the blood-brain barrier (such as P-glycoprotein function). Therefore, it can be used in initial ADME-Tox screening assays to determine if test compounds are likely to penetrate the blood-brain barrier. |
| Quality Control | Bovine Brain Microvascular Endothelial Cells (BBMVEC) test negative for bacteria, yeast, fungi, and mycoplasma. |
| Shipping and Storage | Ace Therapeutics ships frozen cells using dry ice. Upon receiving the frozen cells, immediately move them into liquid nitrogen (-180 °C) for storage. Note: Never can cells be kept at -20 °C, and repeated freezing and thawing of cells is not recommended. |
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are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.