Cat.#: BBM-C-130
| Source | Brain |
| Disease | Normal |
| Species | Bovine |
| Cell Type | Endothelial |
| Description | Bovine Brain Microvascular Endothelial Cells (BBMVEC) from Ace Therapeutics are isolated from microvessels of the bovine brain. The cells are cryopreserved at the second passage. |
| Applications | The Bovine Brain Microvascular Endothelial Cells (BBMVEC), a model for studying the blood-brain barrier (BBB), allows researchers to investigate the transport of drugs across the blood-brain barrier, examine brain endothelial cell tight junctions, and explore the basic biology of brain microvascular endothelial cells more effectively. The endothelial cells in this system exhibit tight junctions (positive for proteins ZO-1 and Claudin-1) and have transport characteristics similar to those found in the blood-brain barrier (such as P-glycoprotein function). Therefore, it can be used in initial ADME-Tox screening assays to determine if test compounds are likely to penetrate the blood-brain barrier. |
| Quality Control | Bovine Brain Microvascular Endothelial Cells (BBMVEC) test negative for bacteria, yeast, fungi, and mycoplasma. |
| Shipping and Storage | Ace Therapeutics ships frozen cells using dry ice. Upon receiving the frozen cells, immediately move them into liquid nitrogen (-180 °C) for storage. Note: Never can cells be kept at -20 °C, and repeated freezing and thawing of cells is not recommended. |
| Cat.# | Name | Description | Price |
|---|---|---|---|
| BBM-C-148 | Rat Astrocytes-adult |
Rat Astrocytes-adult (RA-a) from Ace Therapeutics are isolated from adult CD® IGS rat brains and are cryopreserved after purification. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-135 | Mouse Brain Vascular Pericytes (MBVP) |
Mouse Brain Vascular Pericytes (MBVP) from Ace Therapeutics are isolated from adult mouse brains and cryopreserved at P2. MBVP express Neural/glial antigen 2 (NG2) and α-smooth muscle actin. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-149 | Bovine Astrocytes |
Bovine astrocytes from Ace Therapeutics are isolated from the bovine brain and are cryopreserved at passage one. Bovine astrocytes are characterized by immunofluorescence with antibody specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-137 | Rabbit Cerebrovascular Pericytes Cells |
Rabbit Cerebrovascular Pericytes from Ace Therapeutics are isolated from the brain tissue of a pathogen-free New Zealand White Rabbit. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-133 | Canine Brain Microvascular Endothelial Cells |
Canine Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from the brain of a pathogen-free laboratory beagle dog. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-150 | Rabbit Astrocytes |
Rabbit Astrocytes from Ace Therapeutics are isolated from rabbit brains and are cryopreserved at passage one. Rabbit Astrocytes are characterized by immunofluorescence with antibody specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-124 | Human Astrocytes |
Human Astrocytes from Ace Therapeutics are isolated from the human cerebral cortex, cryopreserved at passage one. Each vial contains at least 5×10^5 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-146 | Sprague-Dawly (SD) Rat Astrocytes |
Characterization: 1. Cell Activity;
– Recovery Viability ≥ 80%.
2. Cell Purity;
– GFAP-positive cells ≥ 70%.
– β-tubulin III- or doublecortin- (Dcx-) positive cells ≤ 10%.
– GalC-positive cells ≤ 10%.
|
inquiry |
| BBM-C-145 | Wistar Rat Astrocytes |
Characterization: 1. Cell Activity;
– Recovery Viability ≥ 80%.
2. Cell Purity;
– GFAP-positive cells ≥ 70%.
– β-tubulin III- or doublecortin- (Dcx-) positive cells ≤ 10%.
– GalC-positive cells ≤ 10%.
|
inquiry |
| BBM-C-147 | Rat Astrocytes-midbrain |
Rat astrocytes-midbrain (RA-mb) from Ace Therapeutics are isolated from CD® IGS rat midbrain and are cryopreserved at P0. RA-mb are characterized by immunofluorescence with antibodies specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.