Ace Therapeutics | Psychiatry

Preclinical Contract Research Organization for Psychiatric Disorders

Ace Therapeutics is a specialized contract research organization dedicated to accelerating the development of novel therapeutics for psychiatric disorders. Our team of neuroscientists, pharmacologists, and research experts brings extensive experience in preclinical research.

We leverage advanced facilities and technical expertise to deliver comprehensive preclinical services, including drug discovery, efficacy evaluation, DMPK, and toxicology evaluation, to support client R&D in psychiatric disorders.

Scientific Excellence
Expert team with deep neuroscience background

Quality Assurance
Rigorous QA processes and documentation

Regulatory Compliance
Commitment to scientifically rigorous practices

Custom Solutions
Tailored research designs for specific needs

Core Services

Preclinical Research and Development Services

Comprehensive preclinical research services covering the entire process of psychiatric drug R&D.

Psychiatric Disease Modeling Services

We provide customized in vivo and in vitro models of psychiatric disorders. These validated models replicate the pathological features of human psychiatric diseases, offering reliable research tools for drug development.

In Vitro Psychiatric Disease Modeling

We provide customized in intro modeling services based on iPSC-dingerived neurons, primary neuron cultures, and brain organoids, enabling clients to conduct early target validation, high-throughput drug screening, and toxicity assessment.

In Vivo Psychiatric Disease Modeling

We provide a variety of customized in vivo animal models, including genetic modification, pharmacological induction, and stress-based models. Supported by a multidimensional validation system integrating behavioral analysis, molecular detection, and brain imaging, we offer end-to-end support for our clients' neuropsychiatric drug development, spanning from target validation and efficacy screening to mechanistic exploration.

Pathological Mechanism Research Services

In-depth analysis of the pathogenesis of psychiatric diseases to provide target validation and mechanism of action research support for drug development.

✔ Neural Circuit Mechanism Research

Neural circuit regulation research based on optogenetics/chemogenetics

✔ Inflammatory Mechanism Research

Microglial activation, cytokine expression level detection

✔ Synaptic Plasticity Research

Synaptic protein expression, dendritic spine density analysis

Preclinical Drug Development

Based on a comprehensive library of psychiatric disease models, providing one-stop drug discovery services from target validation to hit compound screening.

✔ Target Validation Service

CRISPR/Cas9 technology target validation, behavioral evaluation to confirm effectiveness

✔ High-throughput Compound Screening

Supports rapid screening and activity evaluation of compound libraries

✔ Compound Optimization

SAR analysis to improve activity, selectivity and pharmacokinetic properties

Biomarker Development

Develop biomarkers for diagnosis and efficacy evaluation of psychiatric diseases to improve drug R&D efficiency and clinical translation success rate.

✔ Peripheral Blood Biomarkers

miRNA, cytokine, metabolite profile analysis

✔ Cerebrospinal Fluid Biomarkers

Neuropeptide, protein biomarker quantitative detection

✔ Imaging Biomarkers

fMRI brain functional connectivity, structural imaging analysis

Biospecimen Analysis

Provide professional biological sample testing and analysis services to support various sample testing needs in psychiatric disease research with accurate and reliable data.

✔ Neurotransmitter Detection

Quantitative analysis of 5-HT, dopamine, norepinephrine, etc.
✔ Metabolomics Analysis

Comprehensive metabolite profiling based on LC-MS/MS
✔ Proteomics Analysis

Targeted/untargeted protein quantification, phosphorylation modification analysis

Pharmacodynamic Evaluation

Comprehensive and rigorous efficacy evaluation to provide pivotal data support for drug development.

In Vitro Pharmacodynamic Evaluation

✔ Neuronal Cell Viability Assay

MTT/CCK-8 assay, LDH release detection, apoptosis analysis
✔ Neurotransmitter Release Assay

High-performance liquid chromatography, ELISA quantitative analysis
✔ Receptor Binding Assay

Radioligand binding, surface plasmon resonance

In Vivo Pharmacodynamic Evaluation

✔ Comprehensive Behavioral Evaluation

Standardized behavioral test battery for different disease models
✔ Brain Drug Distribution Analysis

Microdialysis, tissue homogenate quantification, mass spectrometry imaging
✔ Positive Drug Control Validation

Comparative efficacy assessment against classical positive drugs

Standardized Data Delivery Content

Raw Data and Spectra

Original experimental data and analytical spectra.

Statistical Analysis Report

Professional statistical analysis and interpretation

Pharmacodynamic Report

Comprehensive efficacy evaluation report

Our Technologies & Platforms

Cutting-edge tools and technologies to support comprehensive psychiatric disorder research

Behavioral & In Vivo Platforms

Comprehensive behavioral testing batteries for assessing cognitive, emotional, and social behaviors in animal models.
Neuroimaging Analysis

Multimodal assessment of brain structure, functional connectivity, and neuro-metabolism using high-field MRI, PET, and photoacoustic imaging.
EEG & Electrophysiology

Advanced electroencephalography and neurophysiological recording systems for assessing brain activity and connectivity.
Histopathology Analysis

Tissue morphology, cellular pathology, and biomarker expression via H&E, IHC, and whole-slide imaging.

Antipsychotic Drug Development Services

Psychiatric Disease Model Development