Ace Therapeutics | Psychiatry

Preclinical Contract Research Organization for Psychiatric Disorders

Ace Therapeutics is a specialized contract research organization dedicated to accelerating the development of novel therapeutics for psychiatric disorders. Our team of neuroscientists, pharmacologists, and research experts brings extensive experience in preclinical research.

We leverage advanced facilities and technical expertise to deliver comprehensive preclinical services, including drug discovery, efficacy evaluation, DMPK, and toxicology evaluation, to support client R&D in psychiatric disorders.

Scientific Excellence
Expert team with deep neuroscience background

Quality Assurance
Rigorous QA processes and documentation

Regulatory Compliance
Commitment to scientifically rigorous practices

Custom Solutions
Tailored research designs for specific needs

Core Services

Preclinical Research and Development Services

Comprehensive preclinical research services covering the entire process of psychiatric drug R&D.

Psychiatric Disease Modeling Services

We provide customized in vivo and in vitro models of psychiatric disorders. These validated models replicate the pathological features of human psychiatric diseases, offering reliable research tools for drug development.

In Vitro Psychiatric Disease Modeling

We provide customized in intro modeling services based on iPSC-dingerived neurons, primary neuron cultures, and brain organoids, enabling clients to conduct early target validation, high-throughput drug screening, and toxicity assessment.

In Vivo Psychiatric Disease Modeling

We provide a variety of customized in vivo animal models, including genetic modification, pharmacological induction, and stress-based models. Supported by a multidimensional validation system integrating behavioral analysis, molecular detection, and brain imaging, we offer end-to-end support for our clients' neuropsychiatric drug development, spanning from target validation and efficacy screening to mechanistic exploration.

Pathological Mechanism Research Services

In-depth analysis of the pathogenesis of psychiatric diseases to provide target validation and mechanism of action research support for drug development.

✔ Neural Circuit Mechanism Research

Neural circuit regulation research based on optogenetics/chemogenetics

✔ Inflammatory Mechanism Research

Microglial activation, cytokine expression level detection

✔ Synaptic Plasticity Research

Synaptic protein expression, dendritic spine density analysis

Preclinical Drug Development

Based on a comprehensive library of psychiatric disease models, providing one-stop drug discovery services from target validation to hit compound screening.

✔ Target Validation Service

CRISPR/Cas9 technology target validation, behavioral evaluation to confirm effectiveness

✔ High-throughput Compound Screening

Supports rapid screening and activity evaluation of compound libraries

✔ Compound Optimization

SAR analysis to improve activity, selectivity and pharmacokinetic properties

Biomarker Development

Develop biomarkers for diagnosis and efficacy evaluation of psychiatric diseases to improve drug R&D efficiency and clinical translation success rate.

✔ Peripheral Blood Biomarkers

miRNA, cytokine, metabolite profile analysis

✔ Cerebrospinal Fluid Biomarkers

Neuropeptide, protein biomarker quantitative detection

✔ Imaging Biomarkers

fMRI brain functional connectivity, structural imaging analysis

Biospecimen Analysis

Provide professional biological sample testing and analysis services to support various sample testing needs in psychiatric disease research with accurate and reliable data.

✔ Neurotransmitter Detection

Quantitative analysis of 5-HT, dopamine, norepinephrine, etc.
✔ Metabolomics Analysis

Comprehensive metabolite profiling based on LC-MS/MS
✔ Proteomics Analysis

Targeted/untargeted protein quantification, phosphorylation modification analysis

Pharmacodynamic Evaluation

Comprehensive and rigorous efficacy evaluation to provide pivotal data support for drug development.

In Vitro Pharmacodynamic Evaluation

✔ Neuronal Cell Viability Assay

MTT/CCK-8 assay, LDH release detection, apoptosis analysis
✔ Neurotransmitter Release Assay

High-performance liquid chromatography, ELISA quantitative analysis
✔ Receptor Binding Assay

Radioligand binding, surface plasmon resonance

In Vivo Pharmacodynamic Evaluation

✔ Comprehensive Behavioral Evaluation

Standardized behavioral test battery for different disease models
✔ Brain Drug Distribution Analysis

Microdialysis, tissue homogenate quantification, mass spectrometry imaging
✔ Positive Drug Control Validation

Comparative efficacy assessment against classical positive drugs

Standardized Data Delivery Content

Raw Data and Spectra

Original experimental data and analytical spectra.

Statistical Analysis Report

Professional statistical analysis and interpretation

Pharmacodynamic Report

Comprehensive efficacy evaluation report

Our Technologies & Platforms

Cutting-edge tools and technologies to support comprehensive psychiatric disorder research

Behavioral Neuroscience Platform

Comprehensive, standardized testing for anxiety, depression, motor function, and cognition. Utilizes validated paradigms and automated tracking systems to support psychiatric research and drug development.

Neuroimaging Platform

Applies structural and functional neuroimaging to identify therapeutic targets and assess drug-target engagement in the brain, providing critical support for psychiatric drug discovery.

Neuro Electrophysiology Platform

Integrates patch-clamp, EEG, and high-density MEA systems to capture neural activity from single channels to complex networks, delivering functional data for psychiatric research.

Autoradiography Platform

Enables high-resolution visualization and quantitative analysis of radiolabeled compounds in tissue sections, assessing drug distribution, target binding, and receptor occupancy.

Molecular Biology & Biochemistry Platform

Equipped with diverse analytical instruments for efficient detection from gene to protein, including qPCR, Western blot, ELISA, and neurotransmitter analysis.

Histological Analysis Platform

Offers a complete workflow of tissue processing, sectioning, and staining, including H&E, IHC, IF, and special stains for high-resolution histopathological evaluation.

Optogenetics Platform

Enables millisecond-precise control of neural circuits in freely behaving animals to support mechanistic research and target validation for psychiatric disorders.

Chemogenetics Platform

Provides reversible activation or inhibition of neuronal activity, serving as a powerful tool for dissecting neural circuit function and validating drug targets.

Antipsychotic Drug Development Services

Psychiatric Disease Model Development