Optogenetics has advanced neuroscience by offering millisecond-precision control over specific neuronal populations. This technique combines optical and genetic methods to express light-sensitive proteins (opsins) in targeted cells, allowing their activity to be instantly turned on or off with specific wavelengths of light.

As a preclinical contract research organization specializing in psychiatric disorders, our optogenetics platform is uniquely positioned to help you validate drug targets and evaluate candidate efficacy. By integrating this powerful technology with our extensive disease-relevant cell and animal models, we provide end-to-end solutions that bridge mechanistic research and drug development.

Fig. 1 Optogenetic stimulation and target output observation in cellular context. (Kumar, S., & Khammash, M., 2022)

Introduction to Optogenetics Platform

Optogenetics technology features two unique characteristics: high temporal and spatial resolution, and cell-type specificity. Its applications span multiple classic experimental animal species (including fruit flies, nematodes, mice, rats, marmosets, and cynomolgus monkeys, among others) and cover various aspects of neuroscience research. These include fundamental studies of neural circuits, learning and memory research, addiction studies, movement disorders, sleep disorders, Parkinson's disease models, as well as animal models of depression and anxiety.
This technology platform enables experiments and data analysis and processing in optogenetics, fiber photometry (including three-color single-channel and three-color multi-channel), calcium imaging, fine behavioral recording, electrophysiological monitoring and detection, pulse stimulation, and more.

Core Technical Service Capabilities Of Our Optogenetics Platform

Ace Therapeutics provides clients with flexible and customized optogenetics technology solutions. Our capabilities span multiple stages, from viral vector construction to behavioral assessment.

Available Services at Optogenetics Platform

Why Choose Our Optogenetics Service Platform?

In psychiatric research, accurately modeling pathological states and precisely evaluating the effects of drug interventions are of paramount importance. The advantages of our platform lie in:

Frequently Asked Questions

References

1. Kumar, S., & Khammash, M. Platforms for optogenetic stimulation and feedback control. Frontiers in bioengineering and biotechnology. (2022).10, 918917.
2. Papp, Mariusz, et al. Optogenetic stimulation of transmission from prelimbic cortex to nucleus accumbens core overcomes resistance to venlafaxine in an animal model of treatment-resistant depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 123 (2023): 110715.