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A412997

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Specification

Cat. No.

SMD1369

Related Diseases

Schizophrenia

Product Name

A412997

Size

Customizable

Price

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Description

A412997 is a selective D4R agonist. -412997 showed significant dose-dependent efficacy in both models. A-412997 binds with high affinity to rat dopamine D4 and human dopamine D4.4 receptors (Ki=12.1 and 7.9 nM, respectively). In contrast to the dopamine D4 receptor agonists PD168077 and CP226269, A-412997 showed a better selectivity profile and no affinity <1000 nM for other dopamine receptors or any other proteins in a panel of seventy different receptors and channels. In functional assays using calcium flux, A-412997 was a potent full agonist at rat dopamine D4 receptors (28.4 nM, intrinsic activity=0.83) and did not activate rat dopamine D2L receptors.

CAS Number

630116-49-3

Chemical Formula

C19H23N3O

Exact Mass

309.1841

Molecular Weight

309.413

Elemental Analysis

C, 73.76; H, 7.49; N, 13.58; O, 5.17

Synonym

A412997; A-412997; A 412997;

IUPAC/Chemical Name

N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide

InChi Key

JFCDMGGMCUKHST-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)

SMILES Code

O=C(NC1=CC=CC(C)=C1)CN2CCC(C3=NC=CC=C3)CC2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.