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Amitifadine HCl

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Specification

Cat. No.

SMD682

Related Diseases

Depression

Product Name

Amitifadine HCl

Size

Customizable

Price

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Description

Amitifadine the only drug ever clinically tested in Phase 3 for treating depression, is a triple reuptake inhibitor (TRI) that simultaneously interacts with human monoamine transporters (MATs) including hSERT, hNET and hDAT. This novel multi-target strategy improves drug efficacy and reduces the toxic side effects of drugs. However, the binding modes accounting for amitifadine's polypharmacological mode of action are still elusive, and extensive exploration of the amitifadine-target interactions between amitifadine and MATs is urgently needed.

CAS Number

410074-74-7 (HCl)

Chemical Formula

C11H12Cl3N

Exact Mass

227.0269

Molecular Weight

264.574

Elemental Analysis

C, 49.94; H, 4.57; Cl, 40.20; N, 5.29

Synonym

Amitifadine; DOV 21,947; EB 1010; Amitifadine HCl; Amitifadine hydrochloride

IUPAC/Chemical Name

3-Azabicyclo(3.1.0)hexane, 1-(3,4-dichlorophenyl)-, (1R,5S)- hydrochloride

InChi Key

KAGBHVBIOJBGBD-NINOIYOQSA-N

InChi Code

InChI=1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H/t8-,11+;/m1./s1

SMILES Code

ClC1=CC=C([C@]23CNC[C@@]2([H])C3)C=C1Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.