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Apimostinel

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Specification

Cat. No.

SMD1392

Related Diseases

Schizophrenia

Related Diseases

Anxiety

Related Diseases

Depression

Product Name

Apimostinel

Size

Customizable

Price

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Description

Apimostinel, also known as NRX-1074, also known as AGN-241660, is a novel antidepressant, acting as a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex, which is under investigation by Naurex (recently acquired by Allergan) for the treatment of major depressive disorder. Its mechanism of action and effects are similar to those of rapastinel (GLYX-13), which is under development as an adjunctive therapy for treatment-resistant depression also by Naurex; however, NRX-1074 is 100-fold more potent by weight and, unlike GLYX-13 (which must be administered via intravenous injection), is orally-active.

CAS Number

1421866-48-9 (free base)

Chemical Formula

C25H37N5O6

Exact Mass

503.2744

Molecular Weight

503.6

Elemental Analysis

C, 59.63; H, 7.41; N, 13.91; O, 19.06

Synonym

NRX-1074; NRX 1074; NRX1074; AGN-241660; AGN241660; AGN 241660. Apimostinel

IUPAC/Chemical Name

(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide

InChi Key

DVBUEXCIEIAXPM-PJUQSVSOSA-N

InChi Code

InChI=1S/C25H37N5O6/c1-15(31)19(26)23(35)29-12-6-10-18(29)22(34)30-13-7-11-25(30,14-17-8-4-3-5-9-17)24(36)28-20(16(2)32)21(27)33/h3-5,8-9,15-16,18-20,31-32H,6-7,10-14,26H2,1-2H3,(H2,27,33)(H,28,36)/t15-,16-,18+,19+,20+,25-/m1/s1

SMILES Code

O=C([C@@]1(CC2=CC=CC=C2)N(C([C@H]3N(C([C@@H](N)[C@H](O)C)=O)CCC3)=O)CCC1)N[C@@H]([C@H](O)C)C(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.