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Aptazapine maleate

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Specification

Cat. No.

SMD678

Related Diseases

Depression

Product Name

Aptazapine maleate

Size

Customizable

Price

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Description

Aptazapine, also known as CGS 7525A, is a tetracyclic antidepressant (TeCA) which was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).

CAS Number

71576-41-5 (maleate)

Chemical Formula

C20H23N3O4

Molecular Weight

369.421

Elemental Analysis

C, 65.03; H, 6.28; N, 11.37; O, 17.32

Synonym

CGS 7525A; CGS-7525A; CGS7525A; Aptazapine maleate

IUPAC/Chemical Name

2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine maleate

InChi Key

JJTOHZLQMBVMPF-BTJKTKAUSA-N

InChi Code

InChI=1S/C16H19N3.C4H4O4/c1-17-9-10-19-14-6-3-2-5-13(14)11-18-8-4-7-15(18)16(19)12-17;5-3(6)1-2-4(7)8/h2-8,16H,9-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code

CN(CC1)CC2N1C3=CC=CC=C3CN4C2=CC=C4.O=C(O)/C=C\C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.