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(±)-Asenapine-13C-d3 HCl

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Specification

Cat. No.

SMD1414

Related Diseases

Schizophrenia

Product Name

(±)-Asenapine-13C-d3 HCl

Size

Customizable

Price

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Description

(±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic. It binds to dopamine D1-4, α-adrenergic, and histamine receptors, as well as the serotonin receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7. (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine, apomorphine, and clonidine, respectively, in rat brain. In vivo, (±)-asenapine increases extracellular dopamine levels in the medial prefrontal cortex, nucleus accumbens, and lateral striatum and suppresses the conditioned avoidance response in rats. It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg. Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.

CAS Number

1261392-55-5

Chemical Formula

C16(13C)H14D3Cl2NO

Exact Mass

325.0909

Molecular Weight

326.2397

Elemental Analysis

C, 62.89; H, 6.18; Cl, 21.73; N, 4.29; O, 4.90

Synonym

(±)-Asenapine-13C-d3 HCl;

IUPAC/Chemical Name

(3aR,12bR)-5-chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride

InChi Key

FNJQDKSEIVVULU-XSYCCUFUSA-N

InChi Code

InChI=1S/C17H16ClNO.ClH/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;/h2-8,14-15H,9-10H2,1H3;1H/t14-,15-;/m0./s1/i1+1D3;

SMILES Code

[H][C@]12C3=C(OC4=C([C@@]1(CN(C2)[13C]([2H])([2H])[2H])[H])C=CC=C4)C=CC(Cl)=C3.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.