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AZD-8529 mesylate

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Specification

Cat. No.

SMD1401

Related Diseases

Schizophrenia

Product Name

AZD-8529 mesylate

Size

50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g

Price

Inquiry

Availability

2 Weeks

Description

AZD-8529 is a a positive allosteric modulator at the mGluR2 receptor. AZD8529 decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. AZD8529 potentiated agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus, and striatum. In monkeys, AZD8529 decreased nicotine self-administration at doses (.3-3 mg/kg) that did not affect food self-administration. AZD8529 also reduced nicotine priming- and cue-induced reinstatement of nicotine seeking after extinction of the drug-reinforced responding. In rats, AZD8529 decreased nicotine-induced accumbens dopamine release. The positive allosteric modulators of metabotropic glutamate receptor 2 should be considered for relapse prevention.

CAS Number

1314217-69-0 (mesylate)

Chemical Formula

C25H28F3N5O6S

Exact Mass

487.18

Molecular Weight

583.5832

Elemental Analysis

C, 51.45; H, 4.84; F, 9.77; N, 12.00; O, 16.45; S, 5.49

Synonym

AZD-8529; AZD8529; AZD 8529; AZD-8529 mesylate

IUPAC/Chemical Name

7-methyl-5-(3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl)-2-(4-(trifluoromethoxy)benzyl)isoindolin-1-one mesylate

InChi Key

HRHCPVNKPOTCGB-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H24F3N5O3.CH4O3S/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25,26)27;1-5(2,3)4/h2-5,10-11,28H,6-9,12-14H2,1H3;1H3,(H,2,3,4)

SMILES Code

O=C1N(CC2=CC=C(OC(F)(F)F)C=C2)CC3=C1C(C)=CC(C4=NC(CN5CCNCC5)=NO4)=C3.OS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.