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BI-409306

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Specification

Cat. No.

SMD1406

Related Diseases

Schizophrenia

Product Name

BI-409306

Size

10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; Click to view more sizes and prices

Price

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Availability

2 Weeks

Description

Osoresnontrine, also known as BI-409306, and SUB 166499, is a potent and selective PDE9A inhibitor with an IC50 of 52 nM. PDE9A is a drug target for cognitive decline in Alzheimer's and other diseases because this enzyme reduces brain levels of the second messenger cyclic guanosine monophosphate. cGMP transduces signals by the neurotransmitters nitric oxide and glutamate.

CAS Number

1189767-28-9

Chemical Formula

C16H17N5O2

Exact Mass

311.1382

Molecular Weight

311.345

Elemental Analysis

C, 61.72; H, 5.50; N, 22.49; O, 10.28

Synonym

BI-409306; BI 409306; BI409306; SUB 166499; SUB-166499; SUB166499; Osoresnontrine;

IUPAC/Chemical Name

6-(pyridin-2-ylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

InChi Key

BZTIJCSHNVZMES-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H17N5O2/c22-16-13-10-18-21(12-4-7-23-8-5-12)15(13)19-14(20-16)9-11-3-1-2-6-17-11/h1-3,6,10,12H,4-5,7-9H2,(H,19,20,22)

SMILES Code

O=C1C2=C(N(C3CCOCC3)N=C2)N=C(CC4=NC=CC=C4)N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.03.00

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.