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BMS-902483

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Specification

Cat. No.

SMD1418

Related Diseases

Schizophrenia

Product Name

BMS-902483

Size

Customizable

Price

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Description

BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients

CAS Number

1192810-88-0

Chemical Formula

C18H20N4O

Exact Mass

308.1637

Molecular Weight

308.385

Elemental Analysis

C, 70.11; H, 6.54; N, 18.17; O, 5.19

Synonym

BMS-902483; BMS 902483; BMS902483.

IUPAC/Chemical Name

(1S,2R,4S)-N-(isoquinolin-3-yl)-4'H-4-azaspiro[bicyclo[2.2.2]octane-2,5'-oxazol]-2'-amine

InChi Key

ZDTPXUKLGIDOCS-SFHVURJKSA-N

InChi Code

InChI=1S/C18H20N4O/c1-2-4-14-10-19-16(9-13(14)3-1)21-17-20-11-18(23-17)12-22-7-5-15(18)6-8-22/h1-4,9-10,15H,5-8,11-12H2,(H,19,20,21)/t18-/m0/s1

SMILES Code

[C@@H]1(CC2)[C@@]3(OC(NC4=CC5=C(C=N4)C=CC=C5)=NC3)C[N@]2CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.