Inquiry

First Name *

Last Name *

Business Email *

Phone

Company/Institution

Job Title

Services or Products of Interest *

When do you expect your project to start?

Project Description

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

* Tick to confirm the Research Use Only (RUO) statement.

Cerlapirdine free base

Inquiry

Specification

Cat. No.

SMD1453

Related Diseases

Schizophrenia

Product Name

Cerlapirdine free base

Size

25.0mg; 50.0mg; 100.0mg; 200.0mg

Price

Inquiry

Availability

2 Weeks

Description

Cerlapirdine, also known as SAM-531, WAY-262,531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in clinical development for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia. As of 2011, it is in phase II clinical trials, and has demonstrated a trend toward efficacy along with a good side effect profile and no incidence of serious adverse events. It exerts its effects by acting as a selective 5-HT6 receptor antagonist.

CAS Number

925448-93-7 (free base)

Chemical Formula

C22H23N3O3S

Exact Mass

409.146

Molecular Weight

409.504

Elemental Analysis

C, 64.53; H, 5.66; N, 10.26; O, 11.72; S, 7.83

Synonym

SAM531; SAM-531; SAM 531; PF-05212365; P -05212365; PF05212365; PF-5212365; P -5212365; PF5212365; WAY-262,531; WAY 262,531; WAY262,531; Cerlapirdine

IUPAC/Chemical Name

N,N-dimethyl-3-[(3-naphthalen-1-ylsulfonyl-2H-indazol-5-yl)oxy]propan-1-amine

InChi Key

NXQGEDVQXVTCDA-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H23N3O3S/c1-25(2)13-6-14-28-17-11-12-20-19(15-17)22(24-23-20)29(26,27)21-10-5-8-16-7-3-4-9-18(16)21/h3-5,7-12,15H,6,13-14H2,1-2H3,(H,23,24)

SMILES Code

O=S(C1=C2C=C(OCCCN(C)C)C=CC2=NN1)(C3=C4C=CC=CC4=CC=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.