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Daridorexant mesylate

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Specification

Cat. No.

SMD1280

Related Diseases

Insomnia

Product Name

Daridorexant mesylate

Size

Customizable

Price

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Description

Daridorexant, also known as Nemorexant and ACT541468, is a new dual orexin receptor antagonist, used in the treatment of Insomnia Disorder in Adult Patients. By specific binding to both orexin receptors, daridorexant inhibits the actions of the wake-promoting orexin (also called hypocretin) neuropeptides. This mechanism avoids a more widespread inhibition of neuronal pathways and associated side effects that are intrinsic to positive allosteric GABA-A receptor modulators.

CAS Number

Daridorexant mesylate

Chemical Formula

C24H27ClN6O5S

Molecular Weight

547.03

Elemental Analysis

C, 52.70; H, 4.98; Cl, 6.48; N, 15.36; O, 14.62; S, 5.86

Synonym

Daridorexant; Daridorexant hydrochloride; Daridorexant HCl; ACT541468; ACT 541468; ACT-541468; Nemorexant;

IUPAC/Chemical Name

Methanone, ((2S)-2-(6-chloro-7-methyl-1H-benzimidazol-2-yl)-2-methyl-1-pyrrolidinyl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)-, mesylate

InChi Key

VMOSCTOMUNHUKN-BQAIUKQQSA-N

InChi Code

InChI=1S/C23H23ClN6O2.CH4O3S/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30;1-5(2,3)4/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28);1H3,(H,2,3,4)/t23-;/m0./s1

SMILES Code

O=C(N1[C@](C)(C2=NC3=CC=C(Cl)C(C)=C3N2)CCC1)C4=CC(OC)=CC=C4N5N=CC=N5.OS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.