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MK-3697

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Specification

Cat. No.

SMD1337

Related Diseases

Insomnia

Product Name

MK-3697

Size

5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; Click to view more sizes and prices

Price

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Availability

2 Weeks

Description

MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists . MK-3697 is also the third insomnia drug, currently being developed by Merck. MK-3697 has Ki = 0.95 nM. Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species.

CAS Number

1224846-01-8

Chemical Formula

C23H21N5O3S

Exact Mass

447.13651

Molecular Weight

447.51

Elemental Analysis

C, 61.73; H, 4.73; N, 15.65; O, 10.73; S, 7.17

Synonym

MK3697; MK-3697; MK 3697.

IUPAC/Chemical Name

N-((5,6-dimethoxypyridin-2-yl)methyl)-5'-methyl-5-(thiazol-2-yl)-[2,3'-bipyridine]-4-carboxamide.

InChi Key

VSOUDUXMPUHJEU-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29)

SMILES Code

O=C(C1=CC(C2=CC(C)=CN=C2)=NC=C1C3=NC=CS3)NCC4=NC(OC)=C(OC)C=C4

Appearance

white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.