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PD184161

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Specification

Cat. No.

SMD1095

Related Diseases

Depression

Product Name

PD184161

Size

5.0mg; 10.0mg; 25.0mg

Price

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Availability

2 Weeks

Description

PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term.

CAS Number

212631-67-9

Chemical Formula

C17H13BrClF2IN2O2

Exact Mass

555.8862

Molecular Weight

557.5583

Elemental Analysis

C, 36.62; H, 2.35; Br, 14.33; Cl, 6.36; F, 6.81; I, 22.76; N, 5.02; O, 5.74

Synonym

PD184161; PD 184161; PD184161; PF1529483 PF3011370 UK287074.

IUPAC/Chemical Name

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide

InChi Key

VJNZMSLGVUSPCF-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25)

SMILES Code

O=C(NOCC1CC1)C2=CC(Br)=C(F)C(F)=C2NC3=CC=C(I)C=C3Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).

HS Tariff Code

2934.99.9001

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.